OABK

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561019

CAS#: 1984862-48-7

Description: OABK is a small molecule switch that can be used to control protein activity. Genetic encoding of OABK using a pyrrolysyl tRNA synthetase/tRNACUA pair in mammalian cells enables the site-specific introduction of a small molecule-removable protecting group into the protein of interest. A phosphine-mediated Staudinger reduction is used to re-activate protein function.


Price and Availability

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OABK is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561019
Name: OABK
CAS#: 1984862-48-7
Chemical Formula: C14H20ClN5O4
Exact Mass:
Molecular Weight: 357.795
Elemental Analysis: C, 47.00; H, 5.63; Cl, 9.91; N, 19.57; O, 17.89Chemical Formula: C14H20ClN5O4 Exact Mass: 357.1204 Molecular Weight: 357.7950 Elemental Analysis: C, 47.00; H, 5.63; Cl, 9.91; N, 19.57; O, 17.89


Synonym: OABK; ortho-azidobenzyloxycarbonyl-L-lysine hydrochloride

IUPAC/Chemical Name: N6-(((4-Azidobenzyl)oxy)carbonyl)-L-lysine hydrochloride

InChi Key: AQUASNYNCOKBBC-YDALLXLXSA-N

InChi Code: InChI=1S/C14H19N5O4.ClH/c15-12(13(20)21)3-1-2-8-17-14(22)23-9-10-4-6-11(7-5-10)18-19-16;/h4-7,12H,1-3,8-9,15H2,(H,17,22)(H,20,21);1H/t12-;/m0./s1

SMILES Code: N[C@@H](CCCCNC(OCC1=CC=C(N=[N+]=[N-])C=C1)=O)C(O)=O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Small Molecule Control of Protein Function through Staudinger Reduction Ji Luo, Qingyang Liu, Kunihiko Morihiro, Alexander Deiters Nat Chem. Author manuscript; available in PMC 2017 Jan 25.Published in final edited form as: Nat Chem. 2016 Nov; 8(11): 1027–1034. Published online 2016 Jul 25. doi: 10.1038/nchem.2573 PMCID: PMC5119652

2: Approximate steady-state properties of lattices of interacting three-state enzyme molecules: a novel phase transition. T L Hill, L Stein Proc Natl Acad Sci U S A. 1979 Mar; 76(3): 1014–1017. PMCID: PMC383177