Hexamethonium bromide | CAS# 55-97-0 (Br) | non-depolarizing NMJ blocker | nAChR antagonist

Hexamethonium bromide
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540194

CAS#: 55-97-0 (Br)

Description: Hexamethonium bromide non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant.

Chemical Structure

Hexamethonium bromide

CAS# 55-97-0 (Br)

Instruction

Theoretical Analysis

MedKoo Cat#: 540194
Name: Hexamethonium bromide
CAS#: 55-97-0 (Br)
Chemical Formula: C12H30Br2N2
Exact Mass: 360.08
Molecular Weight: 362.194
Elemental Analysis: C, 39.79; H, 8.35; Br, 44.12; N, 7.73

Price and Availability

Size	Price	Availability
5g	USD 250	2 Weeks
25g	USD 550	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 60-26-4 (free base) 815-76-9 (monotartrate) 55-97-0 (Br) 60-25-3 (Cl) 60-26-4 (free base) 815-76-9 (monotartrate) 55-97-0 (Br) 60-25-3 (Cl) 2079-78-9 (tartrate)

Synonym: Hexamethionium bromide; Esametina; Simpatoblock; Vegolysen

IUPAC/Chemical Name: N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium bromide

InChi Key: FAPSXSAPXXJTOU-UHFFFAOYSA-L

InChi Code: InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

SMILES Code: C[N+](CCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 362.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: AUBERT H, GAVRILESCU S. [Hexamethonium bromide in therapy of some cardiovascular diseases]. Med Interna (Bucur). 1956 Dec;8(8):1182-9. Romanian. PubMed PMID: 13418082.

2: O'Byrne PM, Thomson NC, Latimer KM, Roberts RS, Morris MM, Daniel EE, Hargreave FE. The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine. J Allergy Clin Immunol. 1985 Jul;76(1):97-103. PubMed PMID: 2861223.

3: GILMORE HR, KOPELMAN H, MCMICHAEL J, MILNE IG. The effect of hexamethonium bromide on the cardiac output and pulmonary circulation. Lancet. 1952 Nov 8;2(6741):898-902. PubMed PMID: 12991634.

4: HUNTER AR. Hexamethonium bromide. Lancet. 1950 Feb 11;1(6598):251. PubMed PMID: 15403290.

5: Sun HZ, Zhao SZ, Ai HB. Microinjection of l-glutamate into the nucleus ambiguus partially inhibits gastric motility through the NMDA receptor - nitric oxide pathway. Can J Physiol Pharmacol. 2014 Jun;92(6):455-9. doi: 10.1139/cjpp-2013-0413. Epub 2014 Apr 3. PubMed PMID: 24830549.

6: FESZT G, FESZT T, FARKAS A. [THE INFLUENCE OF HEXAMETHONIUM BROMIDES ON THE HYPERMETABOLIC ACTION OF CHOLINERGIC SUBSTANCES]. Stud Cercet Fiziol. 1964;9:455-8. Romanian. PubMed PMID: 14286617.

7: FINNEGAN TR, TROUNCE JR. Intolerance to hexamethonium bromide. Br Med J. 1952 Jul 12;2(4775):75-6. PubMed PMID: 14935326; PubMed Central PMCID: PMC2021278.

8: Bříza T, Králová J, Dolenský B, Rimpelová S, Kejík Z, Ruml T, Hajdúch M, Džubák P, Mikula I, Martásek P, Poučková P, Král V. Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization. Chembiochem. 2015 Mar 2;16(4):555-8. doi: 10.1002/cbic.201402662. Epub 2015 Jan 28. PubMed PMID: 25630657.

9: DOUTHWAITE AH, THORNE MJ. The effect of hexamethonium bromide on the stomach. Br Med J. 1951 Jan 20;1(4698):111-114. PubMed PMID: 14812121; PubMed Central PMCID: PMC2068051.

10: STORSTEIN O, TVETEN H. The effect of hexamethonium bromide on the pulmonary circulation. Scand J Clin Lab Invest. 1954;6(3):169-77. PubMed PMID: 13205143.

11: GRATTAN EO. Thyroidectomy in conjunction with the use of hexamethonium bromide. East Afr Med J. 1953 Dec;30(12):507-12. PubMed PMID: 13127821.

12: [Effect of hexamethonium bromide on the stomach]. J Prat Rev Gen Clin Ther. 1951 Mar 29;65(13):142-3. Undetermined Language. PubMed PMID: 14832828.

13: FREEMAN Z. Some observations on the use of hexamethonium bromide in the treatment of ambulant hypertensives. Med J Aust. 1952 May 24;1(21):704-8. PubMed PMID: 14940186.

14: SMIRK FH. Hypotensive actions of hexamethonium bromide and some of its homologues; their use in high blood-pressure. Lancet. 1952 Nov 22;2(6743):1002-5. PubMed PMID: 12991681.

15: BOUHUYS A, JONSSON R, LICHTNECKERT S, LINDELL SE, LUNDGREN C, LUNDIN G. The effect of epinephrine and hexamethonium bromide on the pulmonary ventilation in man. Acta Physiol Pharmacol Neerl. 1959;8:437-46. PubMed PMID: 13803224.

16: PALMER AJ. The management of hypertension with hexamethonium bromide. Med J Aust. 1952 Sep 27;2(13):428-35. PubMed PMID: 13001472.

17: RAPPAPORT F, GROTTO M. A method for prolongation of hexamethonium-bromide activity; preliminary report. Harefuah. 1953 Sep 15;45(6):126-7. PubMed PMID: 13117348.

18: Owoyele BV, Oladejo RO, Ajomale K, Ahmed RO, Mustapha A. Analgesic and anti-inflammatory effects of honey: the involvement of autonomic receptors. Metab Brain Dis. 2014 Mar;29(1):167-73. doi: 10.1007/s11011-013-9458-3. Epub 2013 Dec 10. PubMed PMID: 24318481.

19: LYKKE AW, MULLER HK, ROBERTSON JS. Effects of hexamethonium bromide and beta-amino propionitrile on the tensile strength of the aorta of mice. Nature. 1960 Oct 15;188:238-9. PubMed PMID: 13764537.

20: YOUNG IM. The placental transfer of hexamethonium bromide and the origin of amniotic fluid in the rabbit. J Physiol. 1953 Oct;122(1):93-101. PubMed PMID: 13109743; PubMed Central PMCID: PMC1366180.

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