BGB-290

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206852

CAS#: 1446261-44-1 (free)

Description: BGB-290 is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.


Price and Availability

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BGB-290 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206852
Name: BGB-290
CAS#: 1446261-44-1 (free)
Chemical Formula: C16H15FN4O
Exact Mass: 298.123
Molecular Weight: 298.3214
Elemental Analysis: C, 64.42; H, 5.07; F, 6.37; N, 18.78; O, 5.36


Related CAS #: 2086689-93-0 (hydrate)   2086689-94-1 (maleate)   1446261-44-1 (free)    

Synonym: BGB-290; BGB 290; BGB290.

IUPAC/Chemical Name: (R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one

InChi Key: DENYZIUJOTUUNY-MRXNPFEDSA-N

InChi Code: InChI=1S/C16H15FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6,18H,2-4,7H2,1H3,(H,20,22)/t16-/m1/s1

SMILES Code: FC(C=C1N2)=CC3=C1C4=C2[C@](CCC5)(C)N5CC4=NNC3=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490