Calcium saccharate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540179

CAS#: 5793-89-5 (calcium hydrate)

Description: Calcium saccharate is an oxidized non-cyclic hexose sugar. It may inhibit carcinogenesis and proliferation of cancer cells.


Price and Availability

Size
Price

25g
USD 190
Size
Price

50g
USD 350
Size
Price

100g
USD 550

Calcium saccharate hydrate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 540179
Name: Calcium saccharate
CAS#: 5793-89-5 (calcium hydrate)
Chemical Formula: C6H16CaO12
Exact Mass: 320.0268
Molecular Weight: 320.26
Elemental Analysis: C, 22.50; H, 5.04; Ca, 12.51; O, 59.95


Related CAS #: 5793-88-4 (calcium)   5793-89-5 (calcium hydrate)    

Synonym: Calcium D-saccharate tetrahydrate; L-Gularic Acid;

IUPAC/Chemical Name: calcium (2R,3S,4S,5S)-2,3,4,5-tetrahydroxyhexanedioate tetrahydrate

InChi Key: ZQWFSIZRQANUDA-WQMSYZFBSA-L

InChi Code: InChI=1S/C6H10O8.Ca.4H2O/c7-1(3(9)5(11)12)2(8)4(10)6(13)14;;;;;/h1-4,7-10H,(H,11,12)(H,13,14);;4*1H2/q;+2;;;;/p-2/t1-,2-,3-,4+;;;;;/m0...../s1

SMILES Code: O=C([O-])[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Ca+2]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Garcia AC, Vavrusova M, Skibsted LH. Calcium d-Saccharate: Aqueous Solubility, Complex Formation, and Stabilization of Supersaturation. J Agric Food Chem. 2016 Mar 23;64(11):2352-60. doi: 10.1021/acs.jafc.6b00166. Epub 2016 Mar 9. PubMed PMID: 26934422.

2: Agarwal R, Kusek JW, Pappas MK. A randomized trial of intravenous and oral iron in chronic kidney disease. Kidney Int. 2015 Oct;88(4):905-14. doi: 10.1038/ki.2015.163. Epub 2015 Jun 17. PubMed PMID: 26083656; PubMed Central PMCID: PMC4589436.

3: Calcium-D-glucarate. Altern Med Rev. 2002 Aug;7(4):336-9. Review. PubMed PMID: 12197785.

4: Wang C, Graham DJ, Kane RC, Xie D, Wernecke M, Levenson M, MaCurdy TE, Houstoun M, Ryan Q, Wong S, Mott K, Sheu TC, Limb S, Worrall C, Kelman JA, Reichman ME. Comparative Risk of Anaphylactic Reactions Associated With Intravenous Iron Products. JAMA. 2015 Nov 17;314(19):2062-8. doi: 10.1001/jama.2015.15572. PubMed PMID: 26575062.

5: Shi Q, Leng W, Wazir R, Li J, Yao Q, Mi C, Yang J, Xing A. Intravenous Iron Sucrose versus Oral Iron in the Treatment of Pregnancy with Iron Deficiency Anaemia: A Systematic Review. Gynecol Obstet Invest. 2015;80(3):170-8. doi: 10.1159/000376577. Epub 2015 Mar 25. Review. PubMed PMID: 25824489.

6: Macdougall IC, Strauss WE, McLaughlin J, Li Z, Dellanna F, Hertel J. A randomized comparison of ferumoxytol and iron sucrose for treating iron deficiency anemia in patients with CKD. Clin J Am Soc Nephrol. 2014 Apr;9(4):705-12. doi: 10.2215/CJN.05320513. Epub 2014 Jan 23. PubMed PMID: 24458078; PubMed Central PMCID: PMC3974353.

7: Pieracci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE. A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness*. Crit Care Med. 2014 Sep;42(9):2048-57. doi: 10.1097/CCM.0000000000000408. PubMed PMID: 24797376.

8: Jiang J, Li Y, Feng Z, Yang Y, Zhang P. Glucaric acids from Leonurus japonicus. Fitoterapia. 2015 Dec;107:85-9. doi: 10.1016/j.fitote.2015.10.007. Epub 2015 Oct 23. PubMed PMID: 26526024.

9: Qiu Y, Fang F, Du G, Chen J. [Progress in glucaric acid]. Sheng Wu Gong Cheng Xue Bao. 2015 Apr;31(4):481-90. Review. Chinese. PubMed PMID: 26380405.

10: Rebel A, Beck A, Efron P, Bavry AA, Ang D. Successful Rescue Therapy for Severe Acute Anemia: Managing the Critically Ill Jehovah's Witness. Am Surg. 2015 Jun;81(6):E263-5. PubMed PMID: 26031262.

11: Contreras C, Barnuevo MD, Guillén I, Luque A, Lázaro E, Espadaler J, López-Román J, Villegas JA. Comparative study of the oral absorption of microencapsulated ferric saccharate and ferrous sulfate in humans. Eur J Nutr. 2014;53(2):567-74. doi: 10.1007/s00394-013-0565-z. Epub 2013 Jul 27. PubMed PMID: 23892521.

12: Pieracci FM. The author replies. Crit Care Med. 2015 Jan;43(1):e37. doi: 10.1097/CCM.0000000000000737. PubMed PMID: 25514745.

13: van Eijk LT, Kox M, Pickkers P. Hepcidin as a target of therapy in the treatment of anemia after trauma. Crit Care Med. 2015 Jan;43(1):e36-7. doi: 10.1097/CCM.0000000000000689. PubMed PMID: 25514744.

14: Xie B, Liu Y, Zou H, Son Y, Wang H, Wang H, Shao J. Determination of D-glucaric acid and/or D-glucaro-1,4-lacton in different apple varieties through hydrophilic interaction chromatography. Food Chem. 2016 Jul 15;203:1-7. doi: 10.1016/j.foodchem.2016.02.009. Epub 2016 Feb 2. PubMed PMID: 26948581.

15: Wang C, Wong S, Graham DJ. Risk of Anaphylaxis With Intravenous Iron Products. JAMA. 2016 May 24-31;315(20):2232-3. doi: 10.1001/jama.2016.0965. PubMed PMID: 27218636.

16: Takashi Y, Fukumoto S. [Bone and Nutrition. The relationship between iron and phosphate metabolism]. Clin Calcium. 2015 Jul;25(7):1037-42. doi: CliCa150710371042. Review. Japanese. PubMed PMID: 26119317.

17: Xie B, Zhang Z, Gong T, Zhang N, Wang H, Zou H. Application of metabonomic strategy to discover an unreported active ingredient in LiuWeiDiHuang pills suppressing beta-glucuronidase. Anal Bioanal Chem. 2015 Jan;407(2):609-14. doi: 10.1007/s00216-014-8253-2. Epub 2014 Nov 9. PubMed PMID: 25381611.

18: Shi Q, Li J, Yao Q, Mi C, Yang J, Xing A. Intravenous iron sucrose: an alternative for oral iron in pregnancy with iron deficiency anemia. Ann Hematol. 2015 Mar;94(3):523-5. doi: 10.1007/s00277-014-2189-7. Epub 2014 Aug 16. PubMed PMID: 25123238.

19: Corwin HL, Napolitano LM. Anemia in the critically ill: do we need to live with it?*. Crit Care Med. 2014 Sep;42(9):2140-1. doi: 10.1097/CCM.0000000000000463. PubMed PMID: 25126804.

20: Dai P, Zhu L, Luo F, Lu L, Li Q, Wang L, Wang Y, Wang X, Hu M, Liu Z. Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids. AAPS J. 2015 May;17(3):723-36. doi: 10.1208/s12248-015-9732-x. Epub 2015 Mar 12. PubMed PMID: 25762448; PubMed Central PMCID: PMC4406953.