WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407496
Description: M2698, also known as MSC-2363318A, is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. M2698 was highly potent in vitro (IC50 1 nM for p70S6K, Akt1 and Akt3 inhibition; IC50 17 nM for pGSK3β indirect inhibition) and in vivo (IC50 15 nM for pS6 indirect inhibition), and relatively selective (only 6/264 kinases had an IC50 within 10-fold of p70S6K).
MedKoo Cat#: 407496
Chemical Formula: C21H19ClF3N5O
Exact Mass: 449.123
Molecular Weight: 449.8622
Elemental Analysis: C, 56.07; H, 4.26; Cl, 7.88; F, 12.67; N, 15.57; O, 3.56
Synonym: M2698; M-2698; M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A.
IUPAC/Chemical Name: (S)-4-((2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethyl)amino)quinazoline-8-carboxamide
InChi Key: HXAUJHZZPCBFPN-QGZVFWFLSA-N
InChi Code: InChI=1S/C21H19ClF3N5O/c22-16-6-5-12(9-15(16)21(23,24)25)17(10-30-7-2-8-30)29-20-14-4-1-3-13(19(26)31)18(14)27-11-28-20/h1,3-6,9,11,17H,2,7-8,10H2,(H2,26,31)(H,27,28,29)/t17-/m1/s1
SMILES Code: O=C(C1=CC=CC2=C(N[C@@H](C3=CC=C(Cl)C(C(F)(F)F)=C3)CN4CCC4)N=CN=C12)N