Hematein
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531025

CAS#: 475-25-2

Description: Hematein, also known as Haematein, is an oxidized derivative of Hematoxylin (Haematoxylin) used in staining the staining of cell nuclei in animal tissue. Hematein also can be used in the staining of myelin sheaths and nerve fibers.


Price and Availability

Size
Price

5g
USD 190
50g
USD 1050
Size
Price

10g
USD 350
Size
Price

25g
USD 650

Hematein, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531025
Name: Hematein
CAS#: 475-25-2
Chemical Formula: C16H12O6
Exact Mass: 300.0634
Molecular Weight: 300.266
Elemental Analysis: C, 64.00; H, 4.03; O, 31.97


Related CAS #: 475-25-2 (Hematein)   517-28-2 (Hematoxylin)  

Synonym: Hematein, haematein, Hematoxylin, Haematoxylin, AI3-63013, AI3 63013, AI363013, NSC 7333, NSC-7333, NSC7333

IUPAC/Chemical Name: 3,4,6a,10-tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one

InChi Key: HLUCICHZHWJHLL-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,17,19-21H,5-6H2

SMILES Code: O=C1C=C2CC3(O)C(C4=CC=C(O)C(O)=C4OC3)=C2C=C1O


Technical Data

Appearance:
Light brown to brown solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Panayotacopoulou MT, Boukis D, Issidorides MR. Localization of phospholipids in human catecholamine neurons with Baker's acid haematein. J Neurocytol. 1989 Oct;18(5):593-7. PubMed PMID: 2482342.

2: Elleder M, Lojda Z. Studies in lipid histochemistry. II. The nature of the material stained with acid haematein test and with OTAN reaction in red blood cells. Histochemie. 1970;24(1):21-8. PubMed PMID: 4098193.

3: Roozemond RC. A comparison of the Baker acid Haematein staining of selected regions of rat hypothalamus with the fatty acid composition of their phosphatidyl choline content and their polar lipid fraction as determined by gas liquid chromatography. Histochem J. 1970 May;2(3):219-30. PubMed PMID: 4112993.

4: CAIN AJ. An examination of Baker's acid haematein test for phospholipines. Q J Microsc Sci. 1947 Dec;88(Pt 4):467-78. PubMed PMID: 18904463.

5: LANE NJ. VISUALIZATION OF SITES OF PHOSPHATASE ACTIVITIES BY MEANS OF MORDANTED HAEMATEIN. J Histochem Cytochem. 1965 Mar;13:235-8. PubMed PMID: 14327696.

6: Kroon DB, Goossens EM. The demonstration of phospholipids in certain cells in neurosecretory nuclei in the rat with Baker's acid Haematein after Fixation in glutaraldehyde-formol-calcium. Z Zellforsch Mikrosk Anat. 1967;83(4):527-37. PubMed PMID: 4177719.

7: KROON DB. CERTAIN CELLS IN THE HYPOTHALAMIC NEUROSECRETORY NUCLEI WHICH ARE STAINABLE BY THE ACID-HAEMATEIN TEST FOR PHOSPHOLIPIDS ACCORDING TO BAKER. Z Zellforsch Mikrosk Anat. 1963 Nov 21;61:317-37. PubMed PMID: 14104678.

8: Bronzato M, Zoleo A, Biondi B, Centeno SA. An insight into the metal coordination and spectroscopic properties of artistic Fe and Fe/Cu logwood inks. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:522-9. doi: 10.1016/j.saa.2015.08.042. Epub 2015 Sep 3. PubMed PMID: 26414555.

9: Wu Y, Tang L, Huang L, Han Z, Wang J, Pan H. A low detection limit penicillin biosensor based on single graphene nanosheets preadsorbed with hematein/ionic liquids/penicillinase. Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:92-9. doi: 10.1016/j.msec.2014.02.012. Epub 2014 Feb 17. PubMed PMID: 24863203.

10: Dapson RW, Bain CL. Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. Biotech Histochem. 2015;90(6):401-23. doi: 10.3109/10520295.2015.1021381. Epub 2015 Apr 20. Review. PubMed PMID: 25893688.

11: Liu H, Jiang H, Xia B, Yi D. The Research of Feature Extraction Method of Liver Pathological Image Based on Multispatial Mapping and Statistical Properties. Comput Math Methods Med. 2016;2016:8420350. doi: 10.1155/2016/8420350. Epub 2016 Feb 28. PubMed PMID: 27022407; PubMed Central PMCID: PMC4789065.

12: Commandeur F, Acosta O, Simon A, Mathieu R, Fautrel A, Gnep K, Haigron P, de Crevoisier R. Prostate whole-mount histology reconstruction and registration to MRI for correlating in-vivo observations with biological findings. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:2399-402. doi: 10.1109/EMBC.2015.7318877. PubMed PMID: 26736777.

13: Hung MS, Xu Z, Chen Y, Smith E, Mao JH, Hsieh D, Lin YC, Yang CT, Jablons DM, You L. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. Int J Oncol. 2013 Nov;43(5):1517-22. doi: 10.3892/ijo.2013.2087. Epub 2013 Sep 4. PubMed PMID: 24008396; PubMed Central PMCID: PMC3823374.

14: Smith AA. Hematein chelates of unusual metal ions for tinctorial histochemistry. Biotech Histochem. 2010 Feb;85(1):43-54. doi: 10.3109/10520290903048392. PubMed PMID: 19575317.

15: Kiernan JA, Horobin RW. A special issue devoted to hematoxylin, hematein, and hemalum. Biotech Histochem. 2010 Feb;85(1):5-6. doi: 10.3109/10520290903048368. PubMed PMID: 19548134.

16: Chen B, Ma M, Su X. An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes, hematein, and beta-lactamase on glassy carbon electrode. Anal Chim Acta. 2010 Jul 26;674(1):89-95. doi: 10.1016/j.aca.2010.06.014. Epub 2010 Jun 16. PubMed PMID: 20638504.

17: Cooksey C. Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications. Biotech Histochem. 2010 Feb;85(1):65-82. doi: 10.3109/10520290903048418. PubMed PMID: 19568968.

18: Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons DM, You L. Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library. BMC Cancer. 2009 May 6;9:135. doi: 10.1186/1471-2407-9-135. PubMed PMID: 19419583; PubMed Central PMCID: PMC2696466.

19: Carpentier P, Foquin A, Dorandeu F. A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus. Neurotoxicology. 2012 Aug;33(4):789-95. doi: 10.1016/j.neuro.2011.11.007. Epub 2011 Dec 3. PubMed PMID: 22155333.

20: Marshall PN. Papanicolaou staining--a review. Microsc Acta. 1983 May;87(3):233-43. Review. PubMed PMID: 6195507.