Ferulic Acid
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MedKoo CAT#: 531023

CAS#: 1135-24-6

Description: Ferulic Acid is a fibroblast growth factor receptor 1 (FGFR1) inhibitor that has antioxidant, anti-inflammatory and anticancer properties. Ferulic acid increased monoamine neurotransmitter levels in the brain regions that are relative to mood disorders: the hippocampus and frontal cortex. The increased tend to serotonin and norepinephrine was also found in the hypothalamus after higher dose of ferulic acid treatment. Monoamine oxidase A (MAO-A) activity was inhibited in the frontal cortex and hippocampus when treatment with 40 and 80 mg/kg ferulic acid; while MAO-B activity did not change significantly. Ferulic acid provides neuroprotective effects against a middle cerebral artery occlusion (MCAO)-induced cerebral ischemia.


Chemical Structure

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Ferulic Acid
CAS# 1135-24-6

Theoretical Analysis

MedKoo Cat#: 531023
Name: Ferulic Acid
CAS#: 1135-24-6
Chemical Formula: C10H10O4
Exact Mass: 194.06
Molecular Weight: 194.186
Elemental Analysis: C, 61.85; H, 5.19; O, 32.96

Price and Availability

Size Price Availability Quantity
5g USD 250 2 Weeks
10g USD 400 2 Weeks
25g USD 750 2 Weeks
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Related CAS #: 1135-24-6 (free acid)   1014-83-1 (cis)   537-98-4 (trans)   2309-07-1 (methyl)  

Synonym: Ferulic Acid, Methyl ferulate, trans-Ferulic acid, Coniferic acid, NSC 2821, NSC2821, NSC-2821

IUPAC/Chemical Name: (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

InChi Key: KSEBMYQBYZTDHS-HWKANZROSA-N

InChi Code: InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+

SMILES Code: O=C(O)/C=C/C1=CC=C(O)C(OC)=C1

Appearance: White to light yellow crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
In vitro activity: The cell apoptosis rate and inflammatory cytokine release were examined using flow cytometry and RT-qPCR, respectively, to investigate the protective effect of FA (ferulic acid) on LPS-induced inflammatory injury in BMECs. As shown in Figure 2A, LPS-induced apoptosis of BMECs was obviously inhibited by FA in a dose-dependent manner. Reference: Vet Res. 2021; 52: 104. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278735/
In vivo activity: Compared with the NASH group, the liver coefficient of the NASH + FA group was significantly reduced (P < 0.05). 20 mg/kg of FA (ferulic acid) significantly reduced the activity of ALT and AST in the serum of the HCHF-induced NASH rats (Fig. 1D and E). These results indicate that 20 mg/kg FA reduced early liver damage caused by the HCHF diet without significantly affecting body weight. Reference: J Pharmacol Sci. 2021 Sep;147(1):72-80. https://pubmed.ncbi.nlm.nih.gov/34294375/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.3 264.33
DMF 20.0 102.99
DMF:PBS (pH 7.2) (1:6) 0.1 0.72
Ethanol 24.5 126.17

Preparing Stock Solutions

The following data is based on the product molecular weight 194.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Liu M, Zhang C, Xu X, Zhao X, Han Z, Liu D, Bo R, Li J, Liu Z. Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-κB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation. Vet Res. 2021 Jul 13;52(1):104. doi: 10.1186/s13567-021-00973-3. PMID: 34256834; PMCID: PMC8278735. 2. Du K, Fang X, Li Z. Ferulic acid suppresses interleukin-1β-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1α signaling pathway. Immun Inflamm Dis. 2021 Sep;9(3):710-720. doi: 10.1002/iid3.424. Epub 2021 Jun 2. PMID: 34078001. 3. Wei Z, Xue Y, Xue Y, Cheng J, Lv G, Chu L, Ma Z, Guan S. Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways. J Pharmacol Sci. 2021 Sep;147(1):72-80. doi: 10.1016/j.jphs.2021.05.006. Epub 2021 May 24. PMID: 34294375. 4. Cao L, Li Z, Yang Z, Wang M, Zhang W, Ren Y, Li L, Hu J, Sun Z, Nie S. Ferulic acid positively modulates the inflammatory response to septic liver injury through the GSK-3β/NF-κB/CREB pathway. Life Sci. 2021 Jul 15;277:119584. doi: 10.1016/j.lfs.2021.119584. Epub 2021 May 4. PMID: 33961853.
In vitro protocol: 1. Liu M, Zhang C, Xu X, Zhao X, Han Z, Liu D, Bo R, Li J, Liu Z. Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-κB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation. Vet Res. 2021 Jul 13;52(1):104. doi: 10.1186/s13567-021-00973-3. PMID: 34256834; PMCID: PMC8278735. 2. Du K, Fang X, Li Z. Ferulic acid suppresses interleukin-1β-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1α signaling pathway. Immun Inflamm Dis. 2021 Sep;9(3):710-720. doi: 10.1002/iid3.424. Epub 2021 Jun 2. PMID: 34078001.
In vivo protocol: 1. Wei Z, Xue Y, Xue Y, Cheng J, Lv G, Chu L, Ma Z, Guan S. Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways. J Pharmacol Sci. 2021 Sep;147(1):72-80. doi: 10.1016/j.jphs.2021.05.006. Epub 2021 May 24. PMID: 34294375. 2. Cao L, Li Z, Yang Z, Wang M, Zhang W, Ren Y, Li L, Hu J, Sun Z, Nie S. Ferulic acid positively modulates the inflammatory response to septic liver injury through the GSK-3β/NF-κB/CREB pathway. Life Sci. 2021 Jul 15;277:119584. doi: 10.1016/j.lfs.2021.119584. Epub 2021 May 4. PMID: 33961853.

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1: Ouimet MA, Faig JJ, Yu W, Uhrich KE. Ferulic Acid-Based Polymers with Glycol Functionality as a Versatile Platform for Topical Applications. Biomacromolecules. 2015 Sep 14;16(9):2911-9. doi: 10.1021/acs.biomac.5b00824. Epub 2015 Aug 18. PubMed PMID: 26258440.

2: Xie XG, Dai CC. Degradation of a model pollutant ferulic acid by the endophytic fungus Phomopsis liquidambari. Bioresour Technol. 2015 Mar;179:35-42. doi: 10.1016/j.biortech.2014.11.112. Epub 2014 Dec 5. PubMed PMID: 25514400.

3: Chen J, Lin D, Zhang C, Li G, Zhang N, Ruan L, Yan Q, Li J, Yu X, Xie X, Pang C, Cao L, Pan J, Xu Y. Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems. Metab Brain Dis. 2015 Feb;30(1):129-36. doi: 10.1007/s11011-014-9635-z. Epub 2014 Dec 9. PubMed PMID: 25483788.

4: Koh PO. Ferulic acid attenuates the down-regulation of MEK/ERK/p90RSK signaling pathway in focal cerebral ischemic injury. Neurosci Lett. 2015 Feb 19;588:18-23. doi: 10.1016/j.neulet.2014.12.047. Epub 2014 Dec 24. PubMed PMID: 25543028.

5: Adeboye PT, Bettiga M, Aldaeus F, Larsson PT, Olsson L. Catabolism of coniferyl aldehyde, ferulic acid and p-coumaric acid by Saccharomyces cerevisiae yields less toxic products. Microb Cell Fact. 2015 Sep 21;14:149. doi: 10.1186/s12934-015-0338-x. PubMed PMID: 26392265; PubMed Central PMCID: PMC4578848.

6: Vyrides I, Agathangelou M, Dimitriou R, Souroullas K, Salamex A, Ioannou A, Koutinas M. Novel Halomonas sp. B15 isolated from Larnaca Salt Lake in Cyprus that generates vanillin and vanillic acid from ferulic acid. World J Microbiol Biotechnol. 2015 Aug;31(8):1291-6. doi: 10.1007/s11274-015-1876-4. Epub 2015 May 31. PubMed PMID: 26026278.

7: Nabavi SF, Devi KP, Malar DS, Sureda A, Daglia M, Nabavi SM. Ferulic acid and Alzheimer's disease: promises and pitfalls. Mini Rev Med Chem. 2015;15(9):776-88. Review. PubMed PMID: 26002710.

8: Yang GW, Jiang JS, Lu WQ. Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis. Int J Mol Sci. 2015 Oct 12;16(10):24011-31. doi: 10.3390/ijms161024011. PubMed PMID: 26473837; PubMed Central PMCID: PMC4632735.

9: Maruf AA, Lip H, Wong H, O'Brien PJ. Protective effects of ferulic acid and related polyphenols against glyoxal- or methylglyoxal-induced cytotoxicity and oxidative stress in isolated rat hepatocytes. Chem Biol Interact. 2015 Jun 5;234:96-104. doi: 10.1016/j.cbi.2014.11.007. Epub 2014 Nov 18. PubMed PMID: 25446858.

10: Zhang CY, Zhang H, Dong Y, Ren WG, Chen HW. [Study on compatibility of Salviae Miltiorrhizae Radix et Rhizoma and Chuanxiong Rhizoma based on pharmacokinetics of effective components salvianolic acid B and ferulic acid in rat plasma]. Zhongguo Zhong Yao Za Zhi. 2015 Apr;40(8):1589-93. Chinese. PubMed PMID: 26281604.

11: Fukuda T, Kuroda T, Kono M, Hyoguchi M, Tanaka M, Matsui T. Augmentation of ferulic acid-induced vasorelaxation with aging and its structure importance in thoracic aorta of spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol. 2015 Oct;388(10):1113-7. doi: 10.1007/s00210-015-1171-9. Epub 2015 Aug 27. PubMed PMID: 26310777.

12: Sung JH, Gim SA, Koh PO. Ferulic acid attenuates the cerebral ischemic injury-induced decrease in peroxiredoxin-2 and thioredoxin expression. Neurosci Lett. 2014 Apr 30;566:88-92. doi: 10.1016/j.neulet.2014.02.040. Epub 2014 Feb 26. PubMed PMID: 24582902.

13: Wolszleger M, Stan CD, Apotrosoaei M, Vasincu I, Pânzariu A, Profire L. New hydrazones of ferulic acid: synthesis, characterization and biological activity. Rev Med Chir Soc Med Nat Iasi. 2014 Oct-Dec;118(4):1150-6. PubMed PMID: 25581982.

14: Wang JM, Sheng YC, Ji LL, Wang ZT. Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo. J Zhejiang Univ Sci B. 2014 Jun;15(6):540-7. doi: 10.1631/jzus.B1300250. PubMed PMID: 24903991; PubMed Central PMCID: PMC4116857.

15: Liu XD, Huang P, Lu YH, Ma M, Zhou RB, Yuan LX, Peng XJ. [Pharmacokinetics of loganin, ferulic acid and stilbene glucoside in Bushen Tongluo formula in vivo]. Zhongguo Zhong Yao Za Zhi. 2015 Jun;40(12):2428-34. Chinese. PubMed PMID: 26591537.

16: Chen FX, Wang LK. [Effect of ferulic acid on cholesterol efflux in macrophage foam cell formation and potential mechanism]. Zhongguo Zhong Yao Za Zhi. 2015 Feb;40(3):533-7. Chinese. PubMed PMID: 26084183.

17: Yin Y, Qi F, Song Z, Zhang B, Teng J. Ferulic acid combined with astragaloside IV protects against vascular endothelial dysfunction in diabetic rats. Biosci Trends. 2014 Aug;8(4):217-26. PubMed PMID: 25224628.

18: Ziegler K, Kerimi A, Poquet L, Williamson G. Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4). Arch Biochem Biophys. 2016 Jun 1;599:3-12. doi: 10.1016/j.abb.2016.01.018. Epub 2016 Feb 9. PubMed PMID: 26854723; PubMed Central PMCID: PMC4884672.

19: Zwane EN, Rose SH, van Zyl WH, Rumbold K, Viljoen-Bloom M. Overexpression of Aspergillus tubingensis faeA in protease-deficient Aspergillus niger enables ferulic acid production from plant material. J Ind Microbiol Biotechnol. 2014 Jun;41(6):1027-34. doi: 10.1007/s10295-014-1430-7. Epub 2014 Mar 25. PubMed PMID: 24664515.

20: Bakhtiani PA, Caputo N, Castle JR, El Youssef J, Carroll JM, David LL, Roberts CT Jr, Ward WK. A novel, stable, aqueous glucagon formulation using ferulic acid as an excipient. J Diabetes Sci Technol. 2015 Jan;9(1):17-23. doi: 10.1177/1932296814552476. Epub 2014 Sep 24. PubMed PMID: 25253164; PubMed Central PMCID: PMC4495527.