Fenbendazole
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531022

CAS#: 43210-67-9

Description: Fenbendazole, also known as Panacur, is a benzimidazole-class anthelmintic. Intensive treatments with Fenbendazole were toxic to EMT6 cells in vitro; toxicity increased with incubation time and under conditions of severe hypoxia. Fenbendazole did not alter the dose-response curves for radiation or docetaxel; instead, the agents produced additive cytotoxicities. Febendazole in maximally-intensive regimens did not alter the growth of EMT6 tumors, or increase the antineoplastic effects of radiation.


Price and Availability

Size
Price

5g
USD 190
Size
Price

10g
USD 350
Size
Price

25g
USD 550

Fenbendazole, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531022
Name: Fenbendazole
CAS#: 43210-67-9
Chemical Formula: C15H13N3O2S
Exact Mass: 299.0728
Molecular Weight: 299.348
Elemental Analysis: C, 60.19; H, 4.38; N, 14.04; O, 10.69; S, 10.71


Related CAS #: 43210-67-9   53065-28-4 (-amine)  

Synonym: Fenbendazole, Fenbendazoleamine, Fenbendazol, Panacur, Phenbendasol, Safe-quard, Hoe 881v, Hoe881v. Hoe-881v

IUPAC/Chemical Name: methyl (5-(phenylthio)-1H-benzo[d]imidazol-2-yl)carbamate

InChi Key: HDDSHPAODJUKPD-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)

SMILES Code: O=C(OC)NC1=NC2=CC(SC3=CC=CC=C3)=CC=C2N1


Technical Data

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Griffith R, Yaeger M, Hostetter S, Tell LA, Wetzlich S, Vickroy T, Lillie B, MacFarlane W, Laudenslager T, Whitley E, Dzikamunhenga R, Larson W. Safety of fenbendazole in Chinese ring-necked pheasants (Phasianus colchicus). Avian Dis. 2014 Mar;58(1):8-15. PubMed PMID: 24758107.

2: Soukupova-Markova Z, Doubkova V, Marsalek P, Svobodova Z, Papezikova I, Lang S, Navratil S, Palikova M. Degradation rate of praziquantel and fenbendazole in rainbow trout following oral administration. Neuro Endocrinol Lett. 2015;36 Suppl 1:64-7. PubMed PMID: 26757113.

3: Duan Q, Liu Y, Rockwell S. Fenbendazole as a potential anticancer drug. Anticancer Res. 2013 Feb;33(2):355-62. PubMed PMID: 23393324; PubMed Central PMCID: PMC3580766.

4: Cray C, Watson T, Zaias J, Altman NH. Effect of fenbendazole on an autoimmune mouse model. J Am Assoc Lab Anim Sci. 2013;52(3):286-9. PubMed PMID: 23849411; PubMed Central PMCID: PMC3690450.

5: Mason ME, Voris ND, Ortis HA, Geeding AA, Kaplan RM. Comparison of a single dose of moxidectin and a five-day course of fenbendazole to reduce and suppress cyathostomin fecal egg counts in a herd of embryo transfer-recipient mares. J Am Vet Med Assoc. 2014 Oct 15;245(8):944-51. doi: 10.2460/javma.245.8.944. PubMed PMID: 25285937.

6: Hansen TV, Nejsum P, Friis C, Olsen A, Thamsborg SM. Trichuris suis and Oesophagostomum dentatum show different sensitivity and accumulation of fenbendazole, albendazole and levamisole in vitro. PLoS Negl Trop Dis. 2014 Apr 3;8(4):e2752. doi: 10.1371/journal.pntd.0002752. eCollection 2014 Apr. PubMed PMID: 24699263; PubMed Central PMCID: PMC3974671.

7: Wagil M, Białk-Bielińska A, Puckowski A, Wychodnik K, Maszkowska J, Mulkiewicz E, Kumirska J, Stepnowski P, Stolte S. Toxicity of anthelmintic drugs (fenbendazole and flubendazole) to aquatic organisms. Environ Sci Pollut Res Int. 2015 Feb;22(4):2566-73. doi: 10.1007/s11356-014-3497-0. Epub 2014 Sep 6. PubMed PMID: 25189803; PubMed Central PMCID: PMC4315879.

8: Küster T, Stadelmann B, Aeschbacher D, Hemphill A. Activities of fenbendazole in comparison with albendazole against Echinococcus multilocularis metacestodes in vitro and in a murine infection model. Int J Antimicrob Agents. 2014 Apr;43(4):335-42. doi: 10.1016/j.ijantimicag.2014.01.013. Epub 2014 Feb 12. PubMed PMID: 24646943.

9: Howard JT, O'Nan AT, Maltecca C, Baynes RE, Ashwell MS. Differential Gene Expression across Breed and Sex in Commercial Pigs Administered Fenbendazole and Flunixin Meglumine. PLoS One. 2015 Sep 14;10(9):e0137830. doi: 10.1371/journal.pone.0137830. eCollection 2015. PubMed PMID: 26366864; PubMed Central PMCID: PMC4569569.

10: Bianchi CM, Johnson CB, Howard LL, Crump P. Efficacy of fenbendazole and levamisole treatments in captive Houston toads (Bufo [Anaxyrus] houstonensis). J Zoo Wildl Med. 2014 Sep;45(3):564-8. PubMed PMID: 25314823.

11: Wen AD, Duan LP, Liu CS, Tao Y, Xue J, Wu NB, Jiang B, Zhang HB. [In vitro metabolism of fenbendazole prodrug]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2013 Feb;31(1):68-70. Chinese. PubMed PMID: 24812843.

12: Wu Z, Lee D, Joo J, Shin JH, Kang W, Oh S, Lee DY, Lee SJ, Yea SS, Lee HS, Lee T, Liu KH. CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. Antimicrob Agents Chemother. 2013 Nov;57(11):5448-56. doi: 10.1128/AAC.00843-13. Epub 2013 Aug 19. PubMed PMID: 23959307; PubMed Central PMCID: PMC3811268.

13: Varlamova AI, Arkhipov IA, Odoevskaia IM, Danilevskaia NV, Khalikov SS, Chistiachenko IuS, Dushkin AV. [Efficacy of a new fenbendazole formulation produced by nanotechnology-based drug delivery system against nematodosis]. Med Parazitol (Mosk). 2014 Oct-Dec;(4):43-4. Russian. PubMed PMID: 25812410.

14: Saad AS, Attia AK, Alaraki MS, Elzanfaly ES. Comparative study on the selectivity of various spectrophotometric techniques for the determination of binary mixture of fenbendazole and rafoxanide. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Nov 5;150:682-90. doi: 10.1016/j.saa.2015.05.098. Epub 2015 Jun 4. PubMed PMID: 26093118.

15: Materazzo S, Carradori S, Ferretti R, Gallinella B, Secci D, Cirilli R. Effect of the water content on the retention and enantioselectivity of albendazole and fenbendazole sulfoxides using amylose-based chiral stationary phases in organic-aqueous conditions. J Chromatogr A. 2014 Jan 31;1327:73-9. doi: 10.1016/j.chroma.2013.12.051. Epub 2013 Dec 22. PubMed PMID: 24411094.

16: Howard JT, Baynes RE, Brooks JD, Yeatts JL, Bellis B, Ashwell MS, Routh P, O'Nan AT, Maltecca C. The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine. J Vet Pharmacol Ther. 2014 Dec;37(6):531-41. doi: 10.1111/jvp.12128. Epub 2014 Apr 15. PubMed PMID: 24731191.

17: Gattenuo T, Ketzis J, Shell L. Fenbendazole treatment for Mammomonogamus species infection of a domestic cat on St Kitts, West Indies. J Feline Med Surg. 2014 Oct;16(10):864-6. doi: 10.1177/1098612X14529297. Epub 2014 Apr 7. PubMed PMID: 24710593.

18: Duan Q, Liu Y, Booth CJ, Rockwell S. Use of fenbendazole-containing therapeutic diets for mice in experimental cancer therapy studies. J Am Assoc Lab Anim Sci. 2012 Mar;51(2):224-30. PubMed PMID: 22776123; PubMed Central PMCID: PMC3314526.

19: Li Q, Tan X, Li J, Pan L, Liu X. Glutathione-capped CdTe nanocrystals as probe for the determination of fenbendazole. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Apr 15;141:10-5. doi: 10.1016/j.saa.2015.01.026. Epub 2015 Jan 23. PubMed PMID: 25659737.

20: Reinemeyer CR, Prado JC, Nielsen MK. Comparison of the larvicidal efficacies of moxidectin or a five-day regimen of fenbendazole in horses harboring cyathostomin populations resistant to the adulticidal dosage of fenbendazole. Vet Parasitol. 2015 Nov 30;214(1-2):100-7. doi: 10.1016/j.vetpar.2015.10.003. Epub 2015 Oct 21. PubMed PMID: 26477278.