WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206841
Description: SF2523 is a highly selective and potent dual pan-PI3K/BRD4 inhibitor. SF2523 exhibits a remarkable kinase selectivity inhibiting potently only 4 out of the 232 non-PI3K kinases at the enzyme level, showing broad potency against 19 cancer cell lines in vitro, and exhibiting potent in vivo anti- tumor activity in xenograft studies. SF2523 exhibits demonstrated anti- cancer stem cell and generation of oxidative stress activities. The biological, chemical, and computational profile of SF2523 have been published in J. Med. Chem. 2013, Vol. 56, pages 1922-1939 (doi: 10.1021/jm301522m).
MedKoo Cat#: 206841
Chemical Formula: C19H17NO5S
Exact Mass: 371.0827
Molecular Weight: 371.407
Elemental Analysis: C, 61.44; H, 4.61; N, 3.77; O, 21.54; S, 8.63
Synonym: SF2523; SF-2523; SF 2523.
IUPAC/Chemical Name: 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one
InChi Key: BYTKNUOMWLJVNQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
SMILES Code: O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(OCCO5)C5=C4