T521

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526273

CAS#: 891020-54-5

Description: T521 is a novel specific inhibitor of the PBD of Plk1, but not inhibiting Plk2-3.


Price and Availability

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Price

Size
Price

Size
Price

T521 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526273
Name: T521
CAS#: 891020-54-5
Chemical Formula: C17H14FNO5S2
Exact Mass: 395.0297
Molecular Weight: 395.4194
Elemental Analysis: C, 51.64; H, 3.57; F, 4.80; N, 3.54; O, 20.23; S, 16.22


Synonym: T521, T 521, T521

IUPAC/Chemical Name: 5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)oxazole

InChi Key: MVTLATINKNLPEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14FNO5S2/c1-2-25(20,21)17-16(26(22,23)14-6-4-3-5-7-14)19-15(24-17)12-8-10-13(18)11-9-12/h3-11H,2H2,1H3

SMILES Code: O=S(C1=C(S(=O)(CC)=O)OC(C2=CC=C(F)C=C2)=N1)(C3=CC=CC=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Archambault V, Normandin K. Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators. Cell Cycle. 2017 May 19:1-5. doi: 10.1080/15384101.2017.1325043. [Epub ahead of print] PubMed PMID: 28521657.

2: Chen Y, Zhang J, Li D, Jiang J, Wang Y, Si S. Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain. Oncotarget. 2017 Jan 3;8(1):1234-1246. doi: 10.18632/oncotarget.13603. PubMed PMID: 27902479; PubMed Central PMCID: PMC5352051.

3: Ben Said M, Abbassi MS, Bianchini V, Sghaier S, Cremonesi P, Romanò A, Gualdi V, Hassen A, Luini MV. Genetic characterization and antimicrobial resistance of Staphylococcus aureus isolated from bovine milk in Tunisia. Lett Appl Microbiol. 2016 Dec;63(6):473-481. doi: 10.1111/lam.12672. Epub 2016 Nov 2. PubMed PMID: 27657910.

4: Birmingham BK, Bujac SR, Elsby R, Azumaya CT, Wei C, Chen Y, Mosqueda-Garcia R, Ambrose HJ. Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect? Eur J Clin Pharmacol. 2015 Mar;71(3):341-55. doi: 10.1007/s00228-014-1801-z. Epub 2015 Feb 12. PubMed PMID: 25673568.

5: Birmingham BK, Bujac SR, Elsby R, Azumaya CT, Zalikowski J, Chen Y, Kim K, Ambrose HJ. Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States. Eur J Clin Pharmacol. 2015 Mar;71(3):329-40. doi: 10.1007/s00228-014-1800-0. Epub 2015 Jan 30. PubMed PMID: 25630984.

6: Chen L, Qian J, Sheng Z, Mao Y. [Analysis of function of the 452 bp sequence proceeding the pgiB gene in Bacillus stearothermophilus]. Wei Sheng Wu Xue Bao. 2002 Apr;42(2):175-80. Chinese. PubMed PMID: 12557393.

7: Lesca G, Ollagnon-Roman E, Lachanat J, Dusser A, Edery P, Jeanpierre M, Plauchu H. [Diagnostic trap and difficulties of genetic counseling in a family with neuromuscular disease carriers]. Arch Pediatr. 2001 Sep;8(9):957-60. French. PubMed PMID: 11582937.