Hymenidin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526115

CAS#: 107019-95-4

Description: Hymenidin is a natural antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3ß.


Chemical Structure

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Hymenidin
CAS# 107019-95-4

Theoretical Analysis

MedKoo Cat#: 526115
Name: Hymenidin
CAS#: 107019-95-4
Chemical Formula: C11H12BrN5O
Exact Mass: 309.02
Molecular Weight: 310.155
Elemental Analysis: C, 42.60; H, 3.90; Br, 25.76; N, 22.58; O, 5.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Hymenidin

IUPAC/Chemical Name: N-[(E)-3-(2-Amino-1H-imidazol-5-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide

InChi Key: KHJREOQCERRAME-OWOJBTEDSA-N

InChi Code: InChI=1S/C11H12BrN5O/c12-7-4-9(15-5-7)10(18)14-3-1-2-8-6-16-11(13)17-8/h1-2,4-6,15H,3H2,(H,14,18)(H3,13,16,17)/b2-1+

SMILES Code: O=C(C1=CC(Br)=CN1)NC/C=C/C2=CN=C(N)N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 310.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sun Y, Ai X, Hou J, Ye X, Liu R, Shen S, Li Z, Lu S. Integrated discovery of FOXO1-DNA stabilizers from marine natural products to restore chemosensitivity to anti-EGFR-based therapy for metastatic lung cancer. Mol Biosyst. 2017 Jan 31;13(2):330-337. doi: 10.1039/c6mb00678g. PubMed PMID: 27966721.

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3: Rasapalli S, Kumbam V, Dhawane AN, Golen JA, Lovely CJ, Rheingold AL. Total syntheses of oroidin, hymenidin and clathrodin. Org Biomol Chem. 2013 Jul 7;11(25):4133-7. doi: 10.1039/c3ob40668g. PubMed PMID: 23695419.

4: Scala F, Fattorusso E, Menna M, Taglialatela-Scafati O, Tierney M, Kaiser M, Tasdemir D. Bromopyrrole alkaloids as lead compounds against protozoan parasites. Mar Drugs. 2010 Jul 14;8(7):2162-74. doi: 10.3390/md8072162. PubMed PMID: 20714430; PubMed Central PMCID: PMC2920549.

5: Medeiros MA, Lourenço A, Tavares MR, Curto MJ, Feio SS, Roseiro JC. (-)-Agelasidine A from Agelas clathrodes. Z Naturforsch C. 2006 Jul-Aug;61(7-8):472-6. PubMed PMID: 16989304.

6: Pettit GR, Ducki S, Herald DL, Doubek DL, Schmidt JM, Chapuis JC. Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A. Oncol Res. 2005;15(1):11-20. PubMed PMID: 15839302.

7: Bickmeyer U, Drechsler C, Köck M, Assmann M. Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation. Toxicon. 2004 Jul;44(1):45-51. PubMed PMID: 15225561.

8: Assmann M, Zea S, Köck M. Sventrin, a new bromopyrrole alkaloid from the Caribbean sponge Agelas sventres. J Nat Prod. 2001 Dec;64(12):1593-5. PubMed PMID: 11754625.

9: Kobayashi J, Ohizumi Y, Nakamura H, Hirata Y. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 1986 Oct 15;42(10):1176-7. PubMed PMID: 3770140.