Q8 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526089

CAS#: 1541762-55-3 (HCl)

Description: Q8 is a novel cysteinyl leukotreine receptor antagonist, inhibiting VEGF-independent angiogenesis and exerting an additive anti-angiogenic response with bevacizumab.


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Q8 HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526089
Name: Q8 hydrochloride
CAS#: 1541762-55-3 (HCl)
Chemical Formula: C17H14ClNO2
Exact Mass: 299.0713
Molecular Weight: 299.754
Elemental Analysis: C, 68.12; H, 4.71; Cl, 11.83; N, 4.67; O, 10.67


Related CAS #: 1541762-55-3 (HCl)   1541762-52-0 (free base)    

Synonym: Q8; Q8 hydrochloride

IUPAC/Chemical Name: (E)-2-(2-Quinolin-2-yl-vinyl)-benzene-1,4-diol Hydrochloride

InChi Key: LNPCQDLAMXHIFY-WVLIHFOGSA-N

InChi Code: InChI=1S/C17H13NO2.ClH/c19-15-9-10-17(20)13(11-15)6-8-14-7-5-12-3-1-2-4-16(12)18-14;/h1-11,19-20H;1H/b8-6+;

SMILES Code: OC1=CC=C(O)C=C1/C=C/C2=NC3=CC=CC=C3C=C2.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Dugel PU, Jaffe GJ, Sallstig P, Warburton J, Weichselberger A, Wieland M, Singerman L. Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial. Ophthalmology. 2017 May 24. pii: S0161-6420(16)32413-7. doi: 10.1016/j.ophtha.2017.03.057. [Epub ahead of print] PubMed PMID: 28551167.

2: Choi SK, Schurig-Briccio L, Ding Z, Hong S, Sun C, Gennis RB. Location of the substrate binding site of the cytochrome bo(3) ubiquinol oxidase from Escherichia coli. J Am Chem Soc. 2017 May 24. doi: 10.1021/jacs.7b03883. [Epub ahead of print] PubMed PMID: 28538096.

3: de Vink P, Briels J, Schrader T, Milroy L, Brunsveld L, Ottmann C. Cucurbit[8]uril and 14-3-3 based binary bivalent supramolecular-protein assembly platform and co-crystal structure. Angew Chem Int Ed Engl. 2017 May 16. doi: 10.1002/anie.201701807. [Epub ahead of print] PubMed PMID: 28510303.

4: Zhao M, Lepak AJ, Marchillo K, VanHecker J, Andes DR. In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia Coli in a Murine Thigh Infection Model. Antimicrob Agents Chemother. 2017 Apr 17. pii: AAC.00250-17. doi: 10.1128/AAC.00250-17. [Epub ahead of print] PubMed PMID: 28416552.

5: Han Y, Jin Y, Lee SH, Khadka DB, Cho WJ, Lee KY. Berberine bioisostere Q8 compound stimulates osteoblast differentiation and function in vitro. Pharmacol Res. 2017 May;119:463-475. doi: 10.1016/j.phrs.2017.03.002. Epub 2017 Mar 7. PubMed PMID: 28286134.

6: Qi YB, Wang CY, Lv CY, Lun ZM, Zheng CG. Removal Capacities of Polycyclic Aromatic Hydrocarbons (PAHs) by a Newly Isolated Strain from Oilfield Produced Water. Int J Environ Res Public Health. 2017 Feb 22;14(2). pii: E215. doi: 10.3390/ijerph14020215. PubMed PMID: 28241412; PubMed Central PMCID: PMC5334769.

7: Kliem S, Schmidt R, Vogel M, Hiemisch A, Kiess W, Hilbert A. An 8-item short form of the Eating Disorder Examination-Questionnaire adapted for children (ChEDE-Q8). Int J Eat Disord. 2017 Jan 25. doi: 10.1002/eat.22658. [Epub ahead of print] PubMed PMID: 28122128.

8: Hofmekler T, Bertha M, McCracken C, Martineau B, McKinnon E, Schoen BT, McElhanon BO, Tenjarla G, Kugathasan S, Sauer CG. Infliximab Optimization Based on Therapeutic Drug Monitoring in Pediatric Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2017 Apr;64(4):580-585. doi: 10.1097/MPG.0000000000001302. PubMed PMID: 28079601.

9: Butler CT, Reynolds AL, Tosetto M, Dillon ET, Guiry PJ, Cagney G, O'Sullivan J, Kennedy BN. A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab. J Biol Chem. 2017 Mar 3;292(9):3552-3567. doi: 10.1074/jbc.M116.747766. Epub 2016 Dec 29. PubMed PMID: 28035003; PubMed Central PMCID: PMC5339742.

10: Bazylinski DA, Morillo V, Lefèvre CT, Viloria N, Dubbels BL, Williams TJ. Endothiovibrio diazotrophicus gen. nov., sp. nov., a Novel Nitrogen-Fixing, Sulfur-Oxidizing Gammaproteobacterium Isolated from a Salt Marsh. Int J Syst Evol Microbiol. 2016 Dec 15. doi: 10.1099/ijsem.0.001743. [Epub ahead of print] PubMed PMID: 27983471.

11: Schäfer S, Kickelbick G. Simple and high yield access to octafunctional azido, amine and urea group bearing cubic spherosilicates. Dalton Trans. 2016 Dec 20;46(1):221-226. PubMed PMID: 27924976.

12: Liang WF, Cui LY, Cui JY, Yu KW, Yang S, Wang TM, Guan CG, Zhang C, Xing XH. Biosensor-assisted transcriptional regulator engineering for Methylobacterium extorquens AM1 to improve mevalonate synthesis by increasing the acetyl-CoA supply. Metab Eng. 2017 Jan;39:159-168. doi: 10.1016/j.ymben.2016.11.010. Epub 2016 Dec 3. PubMed PMID: 27919791.

13: Jian X, Li N, Zhang C, Hua Q. In silico profiling of cell growth and succinate production in Escherichia coli NZN111. Bioresour Bioprocess. 2016;3(1):48. Epub 2016 Nov 15. PubMed PMID: 27909649; PubMed Central PMCID: PMC5110578.

14: Yanamandra U, Nair V, Singh S, Gupta A, Mulajkar D, Yanamandra S, Norgais K, Mukherjee R, Singh V, Bhattachar SA, Patyal S, Grewal R, Chopra B. Managing High-Altitude Pulmonary Edema with Oxygen Alone: Results of a Randomized Controlled Trial. High Alt Med Biol. 2016 Dec;17(4):294-299. Epub 2016 Dec 1. PubMed PMID: 27906598.

15: Shi XL, Wu YH, Jin XB, Wang CS, Xu XW. Alteromonas lipolytica sp. nov., a poly-beta-hydroxybutyrate-producing bacterium isolated from surface seawater. Int J Syst Evol Microbiol. 2017 Feb;67(2):237-242. doi: 10.1099/ijsem.0.001604. Epub 2017 Feb 24. PubMed PMID: 27902291.

16: Arahal DR, Lucena T, Macián MC, Ruvira MA, González JM, Lekumberri I, Pinhassi J, Pujalte MJ. Marinomonas blandensis sp. nov., a novel marine gammaproteobacterium. Int J Syst Evol Microbiol. 2016 Dec;66(12):5544-5549. doi: 10.1099/ijsem.0.001554. Epub 2016 Oct 9. PubMed PMID: 27902199.

17: Korman NJ, Sofen H, Fretzin S, Rich P, Zhao Y, Herrera V, Nyirady J, Williams N, Mordin M, Tyring S. Secukinumab provides better relief from the impact of psoriasis on daily activities and personal relationships than etanercept: results of two phase 3 placebo-controlled randomized clinical trials in moderate-to-severe psoriasis. J Dermatolog Treat. 2016 Nov 21:1-6. [Epub ahead of print] PubMed PMID: 27832717.

18: Peyronnet B, Robert G, Comat V, Rouprêt M, Gomez-Sancha F, Cornu JN, Misrai V. Learning curves and perioperative outcomes after endoscopic enucleation of the prostate: a comparison between GreenLight 532-nm and holmium lasers. World J Urol. 2017 Jun;35(6):973-983. doi: 10.1007/s00345-016-1957-5. Epub 2016 Oct 20. PubMed PMID: 27766387.

19: El Ammouri A, Kisra H. [Predictors of medication non-adherence among a Moroccan sample of patients with schizophrenia: A cross sectional study]. Encephale. 2016 Sep 20. pii: S0013-7006(16)30188-9. doi: 10.1016/j.encep.2016.02.022. [Epub ahead of print] French. PubMed PMID: 27663045.

20: Redazione L. Errata corrige: Med Lav 2016;107(3):235-242 - P. Petromilli Nordi Sasso Garcia, C. Dupim Presoto, J. Maroco, J. Alvares Duarte Bonini Campos - Work-related activities that may contribute to musculoskeletal symptoms among dental students: validation study. Med Lav. 2016 Jul 26;107(4):5611. PubMed PMID: 27464905.