U0126-EtOH
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533010

CAS#: 1173097-76-1

Description: U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. This inhibition of MEK1/2 is noncompetitive with ERK and ATP.


Price and Availability

Size
Price

25mg
USD 250
Size
Price

50mg
USD 450
Size
Price

100mg
USD 750

U0126-EtOH, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 533010
Name: U0126-EtOH
CAS#: 1173097-76-1
Chemical Formula: C20H22N6OS2
Exact Mass: 426.1297
Molecular Weight: 426.56
Elemental Analysis: C, 56.32; H, 5.20; N, 19.70; O, 3.75; S, 15.03


Related CAS #: 1173097-76-1 (EtOH)   109511-58-2 (free)  

Synonym: U0126-EtOH; U0126EtOH; U0126 EtOH, U0126, U-0126, U 0126

IUPAC/Chemical Name: (2Z,3Z)-2,3-bis(amino((2-aminophenyl)thio)methylene)succinonitrile compound with ethanol (1:1)

InChi Key: CFQULUVMLGZVAF-OYJDLGDISA-N

InChi Code: InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+;

SMILES Code: CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1. Satoh T, Nakatsuka D, Watanabe Y, et al. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neuroscience letters, 2000, 288(2): 163-166.