Danofloxacin free base
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526066

CAS#: 112398-08-0 (free base)

Description: Danofloxacin is a fluoroquinolone antibiotic used in veterinary medicine.


Price and Availability

Size
Price

200mg
USD 350
Size
Price

500mg
USD 650
Size
Price

1g
USD 950

Danofloxacine, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526066
Name: Danofloxacin free base
CAS#: 112398-08-0 (free base)
Chemical Formula: C19H20FN3O3
Exact Mass: 357.1489
Molecular Weight: 357.3854
Elemental Analysis: C, 63.86; H, 5.64; F, 5.32; N, 11.76; O, 13.43


Related CAS #: 112398-08-0 (free base)   119478-55-6 (mesylate)    

Synonym: Danofloxacine; Danofloxacin; Danofloxacino;

IUPAC/Chemical Name: 1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-oxoquinoline-3-carboxylic acid

InChi Key: QMLVECGLEOSESV-RYUDHWBXSA-N

InChi Code: InChI=1S/C19H20FN3O3/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26)/t11-,12-/m0/s1

SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)=C3)C1=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Klein U, de Jong A, Moyaert H, El Garch F, Leon R, Richard-Mazet A, Rose M, Maes D, Pridmore A, Thomson JR, Ayling RD. Antimicrobial susceptibility monitoring of Mycoplasma hyopneumoniae and Mycoplasma bovis isolated in Europe. Vet Microbiol. 2017 May;204:188-193. doi: 10.1016/j.vetmic.2017.04.012. Epub 2017 Apr 14. PubMed PMID: 28532800.

2: Serrano-Rodríguez JM, Cárceles-García C, Cárceles-Rodríguez CM, Gabarda ML, Serrano-Caballero JM, Fernández-Varón E. Susceptibility and PK/PD relationships of Staphylococcus aureus strains from ovine and caprine with clinical mastitis against five veterinary fluoroquinolones. Vet Rec. 2017 Apr 15;180(15):376. doi: 10.1136/vr.103964. Epub 2017 Feb 17. PubMed PMID: 28213532.

3: Teglia CM, Cámara MS, Vera-Candioti L. Dispersive liquid-liquid microextraction of quinolones in porcine blood: Validation of a CE method using univariate calibration or multivariate curve resolution-alternating least squares for overlapped peaks. Electrophoresis. 2017 Apr;38(8):1122-1129. doi: 10.1002/elps.201600475. Epub 2017 Mar 6. PubMed PMID: 28177131.

4: Yao M, Gao W, Tao H, Yang J, Huang T. The regulation effects of danofloxacin on pig immune stress induced by LPS. Res Vet Sci. 2017 Feb;110:65-71. doi: 10.1016/j.rvsc.2016.11.005. Epub 2016 Nov 6. PubMed PMID: 28159239.

5: Yassine M, Rifai A, Doumyati S, Trivella A, Mazellier P, Budzinski H, Al Iskandarani M. Oxidation of danofloxacin by free chlorine-kinetic study, structural identification of by-products by LC-MS/MS and potential toxicity of by-products using in silico test. Environ Sci Pollut Res Int. 2017 Mar;24(9):7982-7993. doi: 10.1007/s11356-017-8409-7. Epub 2017 Jan 20. PubMed PMID: 28108916.

6: Sweeney MT, Papich MG, Watts JL. New interpretive criteria for danofloxacin antibacterial susceptibility testing against Mannheimia haemolytica and Pasteurella multocida associated with bovine respiratory disease. J Vet Diagn Invest. 2017 Mar;29(2):224-227. doi: 10.1177/1040638716683212. Epub 2017 Jan 8. PubMed PMID: 28064562.

7: Zhang N, Ye X, Wu Y, Huang Z, Gu X, Cai Q, Shen X, Jiang H, Ding H. Determination of the Mutant Selection Window and Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin. PLoS One. 2017 Jan 4;12(1):e0169134. doi: 10.1371/journal.pone.0169134. eCollection 2017. PubMed PMID: 28052123; PubMed Central PMCID: PMC5215565.

8: Santoke H, Cooper WJ. Environmental photochemical fate of selected pharmaceutical compounds in natural and reconstituted Suwannee River water: Role of reactive species in indirect photolysis. Sci Total Environ. 2017 Feb 15;580:626-631. doi: 10.1016/j.scitotenv.2016.12.008. Epub 2016 Dec 20. PubMed PMID: 28011020.

9: Terrado-Campos D, Tayeb-Cherif K, Peris-Vicente J, Carda-Broch S, Esteve-Romero J. Determination of oxolinic acid, danofloxacin, ciprofloxacin, and enrofloxacin in porcine and bovine meat by micellar liquid chromatography with fluorescence detection. Food Chem. 2017 Apr 15;221:1277-1284. doi: 10.1016/j.foodchem.2016.11.029. Epub 2016 Nov 8. PubMed PMID: 27979089.

10: Moreno LZ, da Costa BL, Matajira CE, Gomes VT, Mesquita RE, Silva AP, Moreno AM. Molecular and antimicrobial susceptibility profiling of Streptococcus dysgalactiae isolated from swine. Diagn Microbiol Infect Dis. 2016 Oct;86(2):178-80. doi: 10.1016/j.diagmicrobio.2016.07.020. Epub 2016 Jul 27. PubMed PMID: 27539863.

11: Mzyk DA, Baynes RE, Messenger KM, Martinez M, Smith GW. Pharmacokinetics and distribution in interstitial and pulmonary epithelial lining fluid of danofloxacin in ruminant and preruminant calves. J Vet Pharmacol Ther. 2017 Apr;40(2):179-191. doi: 10.1111/jvp.12346. Epub 2016 Jul 31. PubMed PMID: 27476495.

12: Ferrone V, Carlucci M, Palumbo P, Carlucci G. Development and validation of a MEPS-UHPLC-PDA method for determination of ulifloxacin in human plasma and urine of patients with peripheral arterial disease. J Pharm Biomed Anal. 2016 Sep 5;128:313-21. doi: 10.1016/j.jpba.2016.06.001. Epub 2016 Jun 4. PubMed PMID: 27318081.

13: Chen M, Wen F, Wang H, Zheng N, Wang J. Effect of various storage conditions on the stability of quinolones in raw milk. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Jul;33(7):1147-54. doi: 10.1080/19440049.2016.1184051. Epub 2016 Jun 9. PubMed PMID: 27258809.

14: Otero JA, García-Mateos D, de la Fuente A, Prieto JG, Álvarez AI, Merino G. Effect of bovine ABCG2 Y581S polymorphism on concentrations in milk of enrofloxacin and its active metabolite ciprofloxacin. J Dairy Sci. 2016 Jul;99(7):5731-8. doi: 10.3168/jds.2015-10593. Epub 2016 May 4. PubMed PMID: 27157572.

15: Halwachs S, Kneuer C, Gohlsch K, Müller M, Ritz V, Honscha W. The ABCG2 efflux transporter from rabbit placenta: Cloning and functional characterization. Placenta. 2016 Feb;38:8-15. doi: 10.1016/j.placenta.2015.12.005. Epub 2015 Dec 12. PubMed PMID: 26907376.

16: Braun U, Hässig M, Previtali M, Franchini M, Vögtlin A, Storset AK, Ackermann M. [Interleukin-2 for the treatment of cows with malignant catarrhal fever]. Schweiz Arch Tierheilkd. 2015 Jan;157(1):31-8. German. PubMed PMID: 26753317.

17: Rusch M, Kauschat A, Spielmeyer A, Römpp A, Hausmann H, Zorn H, Hamscher G. Biotransformation of the Antibiotic Danofloxacin by Xylaria longipes Leads to an Efficient Reduction of Its Antibacterial Activity. J Agric Food Chem. 2015 Aug 12;63(31):6897-904. doi: 10.1021/acs.jafc.5b02343. Epub 2015 Aug 4. PubMed PMID: 26189577.

18: Lin L, Zhang Y, Tu X, Xie L, Yue Z, Kang H, Wu W, Luo Y. [Determination of 25 quinolones in cosmetics by liquid chromatography-tandem mass spectrometry]. Se Pu. 2015 Mar;33(3):275-81. Chinese. PubMed PMID: 26182469.

19: Bearson BL, Brunelle BW. Fluoroquinolone induction of phage-mediated gene transfer in multidrug-resistant Salmonella. Int J Antimicrob Agents. 2015 Aug;46(2):201-4. doi: 10.1016/j.ijantimicag.2015.04.008. Epub 2015 May 28. PubMed PMID: 26078016.

20: Yánez-Jácome GS, Aguilar-Caballos MP, Gómez-Hens A. Luminescent determination of quinolones in milk samples by liquid chromatography/post-column derivatization with terbium oxide nanoparticles. J Chromatogr A. 2015 Jul 31;1405:126-32. doi: 10.1016/j.chroma.2015.05.070. Epub 2015 Jun 5. PubMed PMID: 26077970.