ZK93426
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533005

CAS#: 89592-45-0

Description: ZK93426 is a potent, selective and competitive benzodiazepine receptor antagonist (IC50 values are 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus respectively)


Price and Availability

Size
Price

10mg
USD 330
Size
Price

Size
Price

ZK93426, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 533005
Name: ZK93426
CAS#: 89592-45-0
Chemical Formula: C18H20N2O3
Exact Mass: 312.1474
Molecular Weight: 312.37
Elemental Analysis: C, 69.21; H, 6.45; N, 8.97; O, 15.37


Related CAS #: 89592-45-0 (free)   1216792-30-1 (HCl)  

Synonym: ZK93426; ZK 93426; ZK-93426.

IUPAC/Chemical Name: ethyl 4-methyl-5-(propan-2-yloxy)-9H-pyrido[3,4-b]indole-3-carboxylate

InChi Key: VMDUABMKBUKKPG-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H20N2O3/c1-5-22-18(21)17-11(4)15-13(9-19-17)20-12-7-6-8-14(16(12)15)23-10(2)3/h6-10,20H,5H2,1-4H3

SMILES Code: O=C(C1=C(C)C2=C(C=N1)NC3=C2C(OC(C)C)=CC=C3)OCC


Technical Data

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM. Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. doi: 10.1016/j.bmc.2010.08.049. Epub 2010 Sep 29. PubMed PMID: 20888240; PubMed Central PMCID: PMC2972656.

2: You H, Kozuska JL, Paulsen IM, Dunn SM. Benzodiazepine modulation of the rat GABAA receptor α4β3γ2L subtype expressed in Xenopus oocytes. Neuropharmacology. 2010 Nov;59(6):527-33. doi: 10.1016/j.neuropharm.2010.07.011. Epub 2010 Jul 16. PubMed PMID: 20638393.

3: Ferretti V, Gilli P, Borea PA. Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor. Acta Crystallogr B. 2004 Aug;60(Pt 4):481-9. Epub 2004 Jul 19. PubMed PMID: 15258407.

4: Davies M, Bateson AN, Dunn SM. Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor. J Neurochem. 1998 May;70(5):2188-94. PubMed PMID: 9572307.

5: Pinna G, Galici R, Schneider HH, Stephens DN, Turski L. Alprazolam dependence prevented by substituting with the beta-carboline abecarnil. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2719-23. PubMed PMID: 9122263; PubMed Central PMCID: PMC20156.

6: Clifton PG, Cooper SJ. The benzodiazepine partial receptor agonist, bretazenil, provokes a strong hyperphagic response: a meal pattern analysis in free feeding rats. Behav Pharmacol. 1996 Oct;7(5):454-461. PubMed PMID: 11224441.

7: Turner JJ, Hodges H, Sinden JD, Gray JA. Comparison of radial maze performance of rats after ibotenate and quisqualate lesions of the forebrain cholinergic projection system: effects of pharmacological challenge and changes in training regime. Behav Pharmacol. 1992 Aug;3(4):359-73. PubMed PMID: 11224138.

8: Rodgers RJ, Randall JI. Are the analgesic effects of social defeat mediated by benzodiazepine receptors? Physiol Behav. 1987;41(3):279-89. PubMed PMID: 2829247.