ZK93423
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533004

CAS#: 83910-44-5

Description: ZK93423 is a potent benzodiazepine receptor agonist (IC50 = 1 nM). ZK93423 is non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors (Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively).


Price and Availability

Size
Price

10mg
USD 275
Size
Price

Size
Price

ZK93423, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 533004
Name: ZK93423
CAS#: 83910-44-5
Chemical Formula: C23H22N2O4
Exact Mass: 390.158
Molecular Weight: 390.44
Elemental Analysis: C, 70.75; H, 5.68; N, 7.18; O, 16.39


Related CAS #: 83910-44-5 (free)   1216574-52-5 (HCl)  

Synonym: ZK93423; ZK 93423; ZK-93423.

IUPAC/Chemical Name: ethyl 6-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate

InChi Key: ALBKMJDFBZVHAK-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H22N2O4/c1-3-28-23(26)22-18(14-27-2)21-17-11-16(29-13-15-7-5-4-6-8-15)9-10-19(17)25-20(21)12-24-22/h4-12,25H,3,13-14H2,1-2H3

SMILES Code: O=C(C1=C(COC)C2=C(C=N1)NC3=C2C=C(OCC4=CC=CC=C4)C=C3)OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ferretti V, Gilli P, Borea PA. Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor. Acta Crystallogr B. 2004 Aug;60(Pt 4):481-9. Epub 2004 Jul 19. PubMed PMID: 15258407.

2: Zhang H, Larock RC. Synthesis of beta- and gamma-carbolines by the palladium-catalyzed iminoannulation of alkynes. J Org Chem. 2002 Dec 27;67(26):9318-30. PubMed PMID: 12492334.

3: Davies M, Bateson AN, Dunn SM. Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor. J Neurochem. 1998 May;70(5):2188-94. PubMed PMID: 9572307.

4: Rodgers RJ, Randall JI. Are the analgesic effects of social defeat mediated by benzodiazepine receptors? Physiol Behav. 1987;41(3):279-89. PubMed PMID: 2829247.