ZK118182 isopropyl ester

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533000

CAS#: 154927-31-8

Description: ZK118182 isopropyl ester is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM)

Chemical Structure

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ZK118182 isopropyl ester
CAS# 154927-31-8
Instruction

Theoretical Analysis

MedKoo Cat#: 533000
Name: ZK118182 isopropyl ester
CAS#: 154927-31-8
Chemical Formula: C23H37ClO5
Exact Mass: 0.00
Molecular Weight: 429.000
Elemental Analysis: C, 64.40; H, 8.69; Cl, 8.26; O, 18.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ZK118182; ZK 118182; ZK-118182.

IUPAC/Chemical Name: [[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester

InChi Key: CRIBOUOHSHJART-AGICUCTASA-N

InChi Code: InChI=1S/C23H37ClO5/c1-17(2)29-22(27)16-28-13-7-6-11-23(15-19(25)14-21(23)24)12-10-20(26)18-8-4-3-5-9-18/h6-7,10,12,17-21,25-26H,3-5,8-9,11,13-16H2,1-2H3/b7-6-,12-10+/t19-,20-,21-,23?/m1/s1

SMILES Code: O=C(OC(C)C)COC/C=C\CC1(/C=C/[C@H](C2CCCCC2)O)C[C@H](O)C[C@H]1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Sharif, N.A.,Williams, G.W.,Crider, J.Y., et al. Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes. Journal of Ocular Pharmacology and Therapeutics 20(6), 489-508 (2004).

2. Hellberg, M.R.,Conrow, R.E.,Sharif, N.A., et al. 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents. Bioorganic & Medicinal Chemistry 10, 2031-2049 (2002).