ZD 7155 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532996

CAS#: 151801-76-2

Description: ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. ZD 7155 hydrochloride displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes.


Price and Availability

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ZD 7155 hydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532996
Name: ZD 7155 hydrochloride
CAS#: 151801-76-2
Chemical Formula: C26H27ClN6O
Exact Mass:
Molecular Weight: 474.99
Elemental Analysis: C, 65.75; H, 5.73; Cl, 7.46; N, 17.69; O, 3.37


Synonym: ZD 7155 hydrochloride; ZD 7155 hydrochloride; ZD 7155; ZD-7155 .

IUPAC/Chemical Name: 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride

InChi Key: NAGGAAHTUXEGFG-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H

SMILES Code: O=C1N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C5=C(C(CC)=NC(CC)=C5)CC1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Chappellaz ML, Smith FG. Systemic and renal hemodynamic effects of the AT1 receptor antagonist, ZD 7155, and the AT2 receptor antagonist, PD 123319, in conscious lambs. Pflugers Arch. 2007 Jan;453(4):477-86. Epub 2006 Oct 19. PubMed PMID: 17051392.

2: Junggren IL, Zhao X, Sun X, Hedner T. Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J Pharm Pharmacol. 1996 Aug;48(8):829-33. PubMed PMID: 8887734.

3: Maxfield EK, Love A, Cotter MA, Cameron NE. Nerve function and regeneration in diabetic rats: effects of ZD-7155, an AT1 receptor antagonist. Am J Physiol. 1995 Sep;269(3 Pt 1):E530-7. PubMed PMID: 7573431.