ZD6021

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532995

CAS#: 255049-08-2

Description: ZD6021 is a neurokinin 1 receptor antagonist.


Price and Availability

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ZD6021 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532995
Name: ZD6021
CAS#: 255049-08-2
Chemical Formula: C35H35Cl2N3O2S
Exact Mass: 631.1827
Molecular Weight: 632.64
Elemental Analysis: C, 66.45; H, 5.58; Cl, 11.21; N, 6.64; O, 5.06; S, 5.07


Synonym: ZD6021; ZD 6021; ZD-6021.

IUPAC/Chemical Name: 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-[4-[2-[(S)-methylsulfinyl]phenyl]piperidin-1-yl]butyl]-N-methylnaphthalene-1-carboxamide

InChi Key: SJHZTGDJTIZMSK-KPRDSAADSA-N

InChi Code: InChI=1S/C35H35Cl2N3O2S/c1-39(35(41)31-20-24(22-38)19-27-7-3-4-8-29(27)31)23-28(26-11-12-32(36)33(37)21-26)15-18-40-16-13-25(14-17-40)30-9-5-6-10-34(30)43(2)42/h3-12,19-21,25,28H,13-18,23H2,1-2H3/t28-,43+/m1/s1

SMILES Code: O=C(C1=C2C=CC=CC2=CC(C#N)=C1)N(C[C@H](C3=CC=C(Cl)C(Cl)=C3)CCN4CCC(C5=CC=CC=C5[S@](C)=O)CC4)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lindström E, von Mentzer B, Påhlman I, Ahlstedt I, Uvebrant A, Kristensson E, Martinsson R, Novén A, de Verdier J, Vauquelin G. Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J Pharmacol Exp Ther. 2007 Sep;322(3):1286-93. Epub 2007 Jun 15. PubMed PMID: 17575073.