KRP-199

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526005

CAS#: 221164-28-9

Description: KRP-199 is a highly potent and selective antagonist for the AMPA receptors, exhibiting good neuroprotective effects in vivo.

Chemical Structure

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KRP-199
CAS# 221164-28-9
Instruction

Theoretical Analysis

MedKoo Cat#: 526005
Name: KRP-199
CAS#: 221164-28-9
Chemical Formula: C22H14F3N5O7
Exact Mass: 517.08
Molecular Weight: 517.377
Elemental Analysis: C, 51.07; H, 2.73; F, 11.02; N, 13.54; O, 21.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KRP-199

IUPAC/Chemical Name: 7-[4-[[[[(4-Carboxyphenyl)amino]carbonyl]oxy]methyl]-1H-imidazol-1-yl]-3,4-dihydro-3-oxo-6-(trifluoromethyl)-2-quinoxalinecarboxylic acid

InChi Key: AEFZZVQZPBFFPN-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H14F3N5O7/c23-22(24,25)13-5-14-15(28-17(20(34)35)18(31)29-14)6-16(13)30-7-12(26-9-30)8-37-21(36)27-11-3-1-10(2-4-11)19(32)33/h1-7,9H,8H2,(H,27,36)(H,29,31)(H,32,33)(H,34,35)

SMILES Code: O=C(C1=NC2=C(C=C(C(F)(F)F)C(N3C=C(COC(NC4=CC=C(C(O)=O)C=C4)=O)N=C3)=C2)NC1=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 517.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Takano Y, Shiga F, Asano J, Hori W, Fukuchi K, Anraku T, Uno T. Design and synthesis of novel 7-heterocycle-6-trifluoromethyl-3-oxoquinoxaline-2-carboxylic acids bearing a substituted phenyl group as superior AMPA receptor antagonists with good physicochemical properties. Bioorg Med Chem. 2006 Feb 1;14(3):776-92. Epub 2005 Oct 7. PubMed PMID: 16214358.

2: Takano Y, Shiga F, Asano J, Hori W, Anraku T, Uno T. Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl group and improved its good physicochemical properties by introduced CF3 group. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11. PubMed PMID: 15380209.