YM 471

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532990

CAS#: 183173-00-4

Description: YM 471 is an orally active, non-peptide arginine vasopressin (AVP) V1A and V2 receptor antagonist.


Price and Availability

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YM 471 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532990
Name: YM 471
CAS#: 183173-00-4
Chemical Formula: C39H38F2N4O3
Exact Mass: 648.2912
Molecular Weight: 648.75
Elemental Analysis: C, 72.20; H, 5.90; F, 5.86; N, 8.64; O, 7.40


Synonym: YM 471; YM-471; YM471.

IUPAC/Chemical Name: N-[4-[(5Z)-5-[2-(4-dimethylaminopiperidin-1-yl)-2-oxoethylidene]-4,4-difluoro2,3-dihydro-1-benzazepine-1-carbonyl]phenyl]-2-phenylbenzamide

InChi Key: ICRPTZMWRJGNQI-CLIDGEQKSA-N

InChi Code: InChI=1S/C39H38F2N4O3/c1-43(2)30-20-23-44(24-21-30)36(46)26-34-33-14-8-9-15-35(33)45(25-22-39(34,40)41)38(48)28-16-18-29(19-17-28)42-37(47)32-13-7-6-12-31(32)27-10-4-3-5-11-27/h3-19,26,30H,20-25H2,1-2H3,(H,42,47)/b34-26-

SMILES Code: O=C(NC1=CC=C(C(N2CCC(F)(F)/C(C3=CC=CC=C32)=C\C(N4CCC(N(C)C)CC4)=O)=O)C=C1)C5=CC=CC=C5C6=CC=CC=C6


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tahara A, Tsukada J, Tomura Y, Kusayama T, Wada K, Ishii N, Yatsu T, Uchida W, Taniguchi N, Tanaka A. Effect of YM471, an orally active non-peptide arginine vasopressin receptor antagonist, on human vascular smooth muscle cells. J Hypertens. 2002 Sep;20(9):1807-14. PubMed PMID: 12195123.