YM 218

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532984

CAS#: 387816-81-1

Description: YM 218 is a novel, potent, nonpeptide vasopressin V1A receptor-selective antagonist.


Price and Availability

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YM 218 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532984
Name: YM 218
CAS#: 387816-81-1
Chemical Formula: C35H38F2N4O4
Exact Mass: 616.2861
Molecular Weight: 616.71
Elemental Analysis: C, 68.17; H, 6.21; F, 6.16; N, 9.08; O, 10.38


Synonym: YM 218; YM-218; YM218.

IUPAC/Chemical Name: N-[4-[(5Z)-4,4-difluoro-5-[2-oxo-2-(4-piperidin-1-ylpiperidin-1-yl)ethylidene]2,3-dihydro-1-benzazepine-1-carbonyl]phenyl]-2-methylfuran-3-carboxamide

InChi Key: VDUUABBYYOPFAW-WMMMYUQOSA-N

InChi Code: InChI=1S/C35H38F2N4O4/c1-24-28(15-22-45-24)33(43)38-26-11-9-25(10-12-26)34(44)41-21-16-35(36,37)30(29-7-3-4-8-31(29)41)23-32(42)40-19-13-27(14-20-40)39-17-5-2-6-18-39/h3-4,7-12,15,22-23,27H,2,5-6,13-14,16-21H2,1H3,(H,38,43)/b30-23-

SMILES Code: O=C(C1=C(C)OC=C1)NC2=CC=C(C(N3CCC(F)(F)/C(C4=CC=CC=C43)=C\C(N5CCC(N6CCCCC6)CC5)=O)=O)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tahara A, Tsukada J, Tomura Y, Suzuki T, Yatsu T, Shibasaki M. Effect of YM218, a nonpeptide vasopressin V(1A) receptor-selective antagonist, on rat mesangial cell hyperplasia and hypertrophy. Vascul Pharmacol. 2007 Jun;46(6):463-9. Epub 2007 Mar 1. PubMed PMID: 17395547.