YIL781 HCl
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MedKoo CAT#: 532981

CAS#: 1640226-17-0 (HCl)

Description: YIL781 is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). YIL781 displays no significant affinity for the motilin receptor (Ki = 6 μM). It bBlocks the effects of ghrelin on insulin secretion both in vivo and in vitro.

Chemical Structure

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YIL781 HCl
CAS# 1640226-17-0 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 532981
Name: YIL781 HCl
CAS#: 1640226-17-0 (HCl)
Chemical Formula: C24H29ClFN3O2
Exact Mass: 409.22
Molecular Weight: 445.963
Elemental Analysis: C, 64.64; H, 6.55; Cl, 7.95; F, 4.26; N, 9.42; O, 7.18

Price and Availability

Size Price Availability Quantity
5mg USD 280 2 Weeks
10mg USD 500 2 Weeks
25mg USD 850 2 Weeks
1g USD 6450 8 Weeks
2g USD 9650 8 Weeks
5g USD 16950 8 Weeks
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Related CAS #: 875258-85-8 (free base)   1640226-17-0 (HCl)    

Synonym: YIL781; YIL 781; YIL-781; YIL781 HCl; YIL781 hydrochloride

IUPAC/Chemical Name: 6-(4-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]quinazolin-4-one hydrochloride

InChi Key: QQGRMONBDBMLSP-FERBBOLQSA-N

InChi Code: InChI=1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1

SMILES Code: O=C1N(C[C@@H]2CN(C(C)C)CCC2)C(C)=NC3=C1C=C(OC4=CC=C(F)C=C4)C=C3.[H]Cl

Appearance: White to light yellow solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 445.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Moran and Dailey (2009) Gut peptides: targets for antiobesity drug development? Endocrinology 150 2526. PMID: 19372201.

2. Esler et al (2007) Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148 5175. PMID: 17656463.