YIL781 HCl
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MedKoo CAT#: 532981

CAS#: 1640226-17-0 (HCl)

Description: YIL781 is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). YIL781 displays no significant affinity for the motilin receptor (Ki = 6 μM). It bBlocks the effects of ghrelin on insulin secretion both in vivo and in vitro.


Price and Availability

Size
Price

10mg
USD 390
Size
Price

50mg
USD 1790
Size
Price

YIL781 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532981
Name: YIL781 HCl
CAS#: 1640226-17-0 (HCl)
Chemical Formula: C24H29ClFN3O2
Exact Mass: 409.2166
Molecular Weight: 445.9634
Elemental Analysis: C, 64.64; H, 6.55; Cl, 7.95; F, 4.26; N, 9.42; O, 7.18


Related CAS #: 875258-85-8 (free base)   1640226-17-0 (HCl)    

Synonym: YIL781; YIL 781; YIL-781.

IUPAC/Chemical Name: 6-(4-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]quinazolin-4-one hydrochloride

InChi Key: QQGRMONBDBMLSP-FERBBOLQSA-N

InChi Code: InChI=1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1

SMILES Code: O=C1N(C[C@@H]2CN(C(C)C)CCC2)C(C)=NC3=C1C=C(OC4=CC=C(F)C=C4)C=C3.[H]Cl


Technical Data

Appearance:
White to light yellow solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1. Moran and Dailey (2009) Gut peptides: targets for antiobesity drug development? Endocrinology 150 2526. PMID: 19372201.

2. Esler et al (2007) Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148 5175. PMID: 17656463.