WEB2347

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525944

CAS#: 114800-19-0

Description: WEB2347 is a novel very potent and long acting hetrazepinoic PAF-antagonist.


Chemical Structure

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WEB2347
CAS# 114800-19-0

Theoretical Analysis

MedKoo Cat#: 525944
Name: WEB2347
CAS#: 114800-19-0
Chemical Formula: C25H28ClN5OS
Exact Mass: 481.17
Molecular Weight: 482.043
Elemental Analysis: C, 62.29; H, 5.86; Cl, 7.35; N, 14.53; O, 3.32; S, 6.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WEB2347, WEB 2347, WEB-2347

IUPAC/Chemical Name: 6-(2-Chlorophenyl)-8,9-dihydro-1-methyl-N,N-dipropyl-4H,7H-cyclopenta(4,5)thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine-8-carboxamide

InChi Key: SCSIRWUYQVAIRL-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H28ClN5OS/c1-4-10-30(11-5-2)24(32)16-12-18-20(13-16)33-25-22(18)23(17-8-6-7-9-19(17)26)27-14-21-29-28-15(3)31(21)25/h6-9,16H,4-5,10-14H2,1-3H3

SMILES Code: O=C(C1CC(S2)=C(C3=C2N4C(CN=C3C5=CC=CC=C5Cl)=NN=C4C)C1)N(CCC)CCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 482.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sakuma Y, Muramoto K, Harada K, Katayama S, Tsunoda H, Katayama K. Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice. Prostaglandins. 1991 Dec;42(6):541-55. PubMed PMID: 1801063.

2: Sakuma Y, Tsunoda H, Shirato M, Katayama S, Yamatsu I, Katayama K. Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs. Prostaglandins. 1991 Nov;42(5):463-72. PubMed PMID: 1763202.

3: Tsunoda H, Sakuma Y, Harada K, Muramoto K, Katayama S, Horie T, Shimomura N, Clark R, Miyazawa S, Okano K, et al. Effects of a novel PAF antagonist, E6123, on PAF-induced biological responses. Agents Actions Suppl. 1990;31:251-4. PubMed PMID: 2080757.