WEB2347

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525944

CAS#: 114800-19-0

Description: WEB2347 is a novel very potent and long acting hetrazepinoic PAF-antagonist.


Price and Availability

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WEB2347 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525944
Name: WEB2347
CAS#: 114800-19-0
Chemical Formula: C25H28ClN5OS
Exact Mass: 481.1703
Molecular Weight: 482.043
Elemental Analysis: C, 62.29; H, 5.86; Cl, 7.35; N, 14.53; O, 3.32; S, 6.65


Synonym: WEB2347, WEB 2347, WEB-2347

IUPAC/Chemical Name: 6-(2-Chlorophenyl)-8,9-dihydro-1-methyl-N,N-dipropyl-4H,7H-cyclopenta(4,5)thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine-8-carboxamide

InChi Key: SCSIRWUYQVAIRL-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H28ClN5OS/c1-4-10-30(11-5-2)24(32)16-12-18-20(13-16)33-25-22(18)23(17-8-6-7-9-19(17)26)27-14-21-29-28-15(3)31(21)25/h6-9,16H,4-5,10-14H2,1-3H3

SMILES Code: O=C(C1CC(S2)=C(C3=C2N4C(CN=C3C5=CC=CC=C5Cl)=NN=C4C)C1)N(CCC)CCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Sakuma Y, Muramoto K, Harada K, Katayama S, Tsunoda H, Katayama K. Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice. Prostaglandins. 1991 Dec;42(6):541-55. PubMed PMID: 1801063.

2: Sakuma Y, Tsunoda H, Shirato M, Katayama S, Yamatsu I, Katayama K. Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs. Prostaglandins. 1991 Nov;42(5):463-72. PubMed PMID: 1763202.

3: Tsunoda H, Sakuma Y, Harada K, Muramoto K, Katayama S, Horie T, Shimomura N, Clark R, Miyazawa S, Okano K, et al. Effects of a novel PAF antagonist, E6123, on PAF-induced biological responses. Agents Actions Suppl. 1990;31:251-4. PubMed PMID: 2080757.