Okicenone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525935

CAS#: 137018-54-3

Description: Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation.


Price and Availability

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Okicenone is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525935
Name: Okicenone
CAS#: 137018-54-3
Chemical Formula: C15H14O4
Exact Mass: 258.0892
Molecular Weight: 258.273
Elemental Analysis: C, 69.76; H, 5.46; O, 24.78


Synonym: Okicenone

IUPAC/Chemical Name: 4,6,9-Trihydroxy-8-methyl-3,4-dihydro-2H-anthracen-1-one

InChi Key: LIETVYHJBSLSSW-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14O4/c1-7-4-9(16)5-8-6-10-11(17)2-3-12(18)14(10)15(19)13(7)8/h4-6,11,16-17,19H,2-3H2,1H3

SMILES Code: O=C1CCC(O)C2=C1C(O)=C3C(C)=CC(O)=CC3=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wang XJ, Xiang ZD, Gong DL, Wang JD, Liu CX, Zhu ZX, Yan YJ, Xiang WS. A new okicenone analog from Streptomyces sp. NEAU-W13. J Antibiot (Tokyo). 2011 Jun;64(6):459-60. doi: 10.1038/ja.2011.22. Epub 2011 Mar 30. PubMed PMID: 21448189.

2: Meisner NC, Hintersteiner M, Mueller K, Bauer R, Seifert JM, Naegeli HU, Ottl J, Oberer L, Guenat C, Moss S, Harrer N, Woisetschlaeger M, Buehler C, Uhl V, Auer M. Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol. 2007 Aug;3(8):508-15. Epub 2007 Jul 15. PubMed PMID: 17632515.

3: Funayama S, Ishibashi M, Komiyama K, Omura S. A new antibiotic, okicenone. II. Physico-chemical properties and structure elucidation. J Antibiot (Tokyo). 1991 Aug;44(8):819-23. PubMed PMID: 1917696.

4: Komiyama K, Funayama S, Anraku Y, Ishibashi M, Takahashi Y, Kawakami T, Omura S. A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics. J Antibiot (Tokyo). 1991 Aug;44(8):814-8. PubMed PMID: 1917695.