WRC-0571

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532973

CAS#: 501667-77-2

Description: WRC-0571 is a highly potent and selective, non-xanthine antagonist of A1 adenosine receptors.

Chemical Structure

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WRC-0571
CAS# 501667-77-2
Instruction

Theoretical Analysis

MedKoo Cat#: 532973
Name: WRC-0571
CAS#: 501667-77-2
Chemical Formula: C17H26N6O
Exact Mass: 330.22
Molecular Weight: 330.440
Elemental Analysis: C, 61.79; H, 7.93; N, 25.43; O, 4.84

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WRC-0571; WRC 0571; WRC0571.

IUPAC/Chemical Name: 5-[[9-methyl-8-[methyl(propan-2-yl)amino]purin-6-yl]amino]bicyclo[2.2.1]heptan-2-ol

InChi Key: FTVZUYADPTUEKI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H26N6O/c1-9(2)22(3)17-21-14-15(18-8-19-16(14)23(17)4)20-12-6-11-5-10(12)7-13(11)24/h8-13,24H,5-7H2,1-4H3,(H,18,19,20)

SMILES Code: OC1C(C2)CC(NC3=C4N=C(N(C)C(C)C)N(C)C4=NC=N3)C2C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 330.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Clark AN, Youkey R, Liu X, Jia L, Blatt R, Day YJ, Sullivan GW, Linden J, Tucker AL. A1 adenosine receptor activation promotes angiogenesis and release of VEGF from monocytes. Circ Res. 2007 Nov 26;101(11):1130-8. Epub 2007 Sep 27. PubMed PMID: 17901362.

2: Shryock JC, Ozeck MJ, Belardinelli L. Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells. Mol Pharmacol. 1998 May;53(5):886-93. PubMed PMID: 9584215.

3: Jin X, Shepherd RK, Duling BR, Linden J. Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J Clin Invest. 1997 Dec 1;100(11):2849-57. PubMed PMID: 9389751; PubMed Central PMCID: PMC508491.

4: Auchampach JA, Jin X, Wan TC, Caughey GH, Linden J. Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Mol Pharmacol. 1997 Nov;52(5):846-60. PubMed PMID: 9351976.

5: Martin PL, Wysocki RJ Jr, Barrett RJ, May JM, Linden J. Characterization of 8-(N-methylisopropyl)amino-N6-(5'-endohydroxy- endonorbornyl)-9-methyladenine (WRC-0571), a highly potent and selective, non-xanthine antagonist of A1 adenosine receptors. J Pharmacol Exp Ther. 1996 Feb;276(2):490-9. PubMed PMID: 8632314.