WIN 64338 hydrochloride
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MedKoo CAT#: 532971

CAS#: 163727-74-0

Description: WIN 64338 hydrochloride is a potent, non-peptide, competitive bradykinin B2 receptor antagonist.WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).


Price and Availability

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Price

10mg
USD 310
Size
Price

Size
Price

WIN 64338 hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532971
Name: WIN 64338 hydrochloride
CAS#: 163727-74-0
Chemical Formula: C45H69Cl2N4OP
Exact Mass:
Molecular Weight: 783.95
Elemental Analysis: C, 68.95; H, 8.87; Cl, 9.04; N, 7.15; O, 2.04; P, 3.95


Related CAS #: 163727-74-0 (HCl)   151039-63-3(free)  

Synonym: WIN 64338 hydrochloride; WIN 64338 HCl; WIN 64338; WIN64338; WIN-64338.

IUPAC/Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride

InChi Key: YYJGBEZPVOUBMJ-KRFCICRISA-N

InChi Code: InChI=1S/C45H67N4OP.2ClH/c1-4-7-30-51(31-8-5-2,32-9-6-3)35-36-25-28-42(29-26-36)46-44(50)43(34-37-24-27-38-18-16-17-19-39(38)33-37)49-45(47-40-20-12-10-13-21-40)48-41-22-14-11-15-23-41;;/h16-19,24-29,33,40-41,43H,4-15,20-23,30-32,34-35H2,1-3H3,(H2-,46,47,48,49,50);2*1H/t43-;;/m0../s1

SMILES Code: CCCC[P+](CCCC)(CC1=CC=C(NC([C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC=C5C=CC=CC5=C4)=O)C=C1)CCCC.[H]Cl.[Cl-]


Technical Data

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Scherrer D, Schmidlin F, Lach E, Da Silva A, Landry Y, Gies JP. Effect of WIN 64338, a B2 bradykinin receptor antagonist on guinea-pig tracheal smooth muscle cells in culture. Fundam Clin Pharmacol. 1998;12(2):188-93. PubMed PMID: 9565773.

2: Hall JM, Figini M, Butt SK, Geppetti P. Inhibition of bradykinin-evoked trigeminal nerve stimulation by the non-peptide bradykinin B2 receptor antagonist WIN 64338 in vivo and in vitro. Br J Pharmacol. 1995 Dec;116(8):3164-8. PubMed PMID: 8719791; PubMed Central PMCID: PMC1909173.

3: Scherrer D, Daeffler L, Trifilieff A, Gies JP. Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br J Pharmacol. 1995 Aug;115(7):1127-8. PubMed PMID: 7582533; PubMed Central PMCID: PMC1908803.

4: Sawutz DG, Salvino JM, Dolle RE, Seoane PR, Farmer SG. Pharmacology and structure--activity relationships of the nonpeptide bradykinin receptor antagonist WIN 64338. Can J Physiol Pharmacol. 1995 Jul;73(7):805-11. Review. PubMed PMID: 8846413.

5: Wirth KJ, Schölkens BA, Wiemer G. The bradykinin B2 receptor antagonist WIN 64338 inhibits the effect of des-Arg9-bradykinin in endothelial cells. Eur J Pharmacol. 1994 Dec 15;288(1):R1-2. PubMed PMID: 7705460.

6: Sawutz DG, Salvino JM, Dolle RE, Casiano F, Ward SJ, Houck WT, Faunce DM, Douty BD, Baizman E, Awad MM, et al. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4693-7. PubMed PMID: 8197121; PubMed Central PMCID: PMC43854.