WIN 62,577

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532970

CAS#: 144177-32-2

Description: WIN 62,577 is a mAChR allosteric antagonist.


Price and Availability

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Price

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WIN 62,577 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532970
Name: WIN 62,577
CAS#: 144177-32-2
Chemical Formula: C29H31N3O
Exact Mass: 437.2467
Molecular Weight: 437.59
Elemental Analysis: C, 79.60; H, 7.14; N, 9.60; O, 3.66


Synonym: WIN 62,577; WIN62,577; WIN-62,577.

IUPAC/Chemical Name: (1R,3aS,3bR,15aR,15bS,17aS)-1-ethynyl-15a,17a-dimethyl-2,3,3a,3b,4,5,15,15a,15b,16,17,17a-dodecahydro-1H-benzo[4,5]imidazo[2,1-b]cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-ol

InChi Key: YBCYJDNOPAFFOW-XOAARHKISA-N

InChi Code: InChI=1S/C29H31N3O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24/h1,5-8,15,17,20-22,33H,9-14,16H2,2-3H3/t20-,21+,22+,27+,28+,29+/m1/s1

SMILES Code: O[C@@]1(C#C)CC[C@@]2([H])[C@]3([H])CCC4=CC5=NC6=NC7=CC=CC=C7N6C=C5C[C@]4(C)[C@@]3([H])CC[C@@]21C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Schober DA, Croy CH, Xiao H, Christopoulos A, Felder CC. Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites. Mol Pharmacol. 2014 Jul;86(1):116-23. doi: 10.1124/mol.114.091785. Epub 2014 May 7. PubMed PMID: 24807966.

2: Lanzafame AA, Sexton PM, Christopoulos A. Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors. Mol Pharmacol. 2006 Aug;70(2):736-46. Epub 2006 May 18. PubMed PMID: 16709648.

3: Lazareno S, Popham A, Birdsall NJ. Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors. Mol Pharmacol. 2002 Dec;62(6):1492-505. PubMed PMID: 12435818.

4: Duvilanski BH, Pisera D, Seilicovich A, del Carmen Díaz M, Lasaga M, Isovich E, Velardez MO. Interaction between substance P and TRH in the control of prolactin release. J Endocrinol. 2000 Aug;166(2):373-80. PubMed PMID: 10927626.

5: Seguin L, Le Marouille-Girardon S, Millan MJ. Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: a comparison to other classes of antinociceptive agent. Pain. 1995 May;61(2):325-43. PubMed PMID: 7659444.

6: Isovich E, del Carmen Díaz M, Lasaga M, Pisera D, Zambruno C, Theas MS, Seilicovich A, Duvilanski BH. Involvement of hypothalamic substance P in the effect of prolactin on dopamine release. Neuroreport. 1994 Sep 8;5(14):1752-4. PubMed PMID: 7530063.