JN403

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525890

CAS#: 942606-12-4

Description: JN403 is a selective nicotinic acetylcholine receptor alpha7 agonist.


Price and Availability

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JN403 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525890
Name: JN403
CAS#: 942606-12-4
Chemical Formula: C16H21FN2O2
Exact Mass: 292.1587
Molecular Weight: 292.3544
Elemental Analysis: C, 65.73; H, 7.24; F, 6.50; N, 9.58; O, 10.94


Synonym: JN403

IUPAC/Chemical Name: (1-Aza-bicyclo[2.2.2]oct-3(S)--yl)-carbamic acid 1(S)-(2-fluoro-phenyl)-ethyl ester

InChi Key: CKBCVTOFGWWVMT-OAHLLOKOSA-N

InChi Code: InChI=1S/C16H21FN2O2/c17-14-4-2-1-3-12(14)7-10-21-16(20)18-15-11-19-8-5-13(15)6-9-19/h1-4,13,15H,5-11H2,(H,18,20)/t15-/m1/s1

SMILES Code: O=C(OCCC1=CC=CC=C1F)N[C@@H]2C[N@]3CCC2CC3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lilja AM, Malmsten L, Röjdner J, Voytenko L, Verkhratsky A, Ögren SO, Nordberg A, Marutle A. Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs. Neural Plast. 2015;2015:370432. doi: 10.1155/2015/370432. Epub 2015 Jul 15. PubMed PMID: 26257960; PubMed Central PMCID: PMC4518185.

2: Arias HR, De Rosa MJ, Bergé I, Feuerbach D, Bouzat C. Differential pharmacological activity of JN403 between α7 and muscle nicotinic acetylcholine receptors. Biochemistry. 2013 Nov 26;52(47):8480-8. doi: 10.1021/bi4012572. Epub 2013 Nov 11. PubMed PMID: 24164482.

3: Chen SG, Gu RX, Dai H, Wei DQ. Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease. J Mol Graph Model. 2013 Feb;39:98-107. doi: 10.1016/j.jmgm.2012.11.008. Epub 2012 Nov 29. PubMed PMID: 23261879.

4: Ni R, Marutle A, Nordberg A. Modulation of α7 nicotinic acetylcholine receptor and fibrillar amyloid-β interactions in Alzheimer's disease brain. J Alzheimers Dis. 2013;33(3):841-51. doi: 10.3233/JAD-2012-121447. PubMed PMID: 23042213.

5: Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A. Functional interactions of fibrillar and oligomeric amyloid-β with alpha7 nicotinic receptors in Alzheimer's disease. J Alzheimers Dis. 2011;23(2):335-47. doi: 10.3233/JAD-2010-101242. PubMed PMID: 21116052.

6: Arias HR, Gu RX, Feuerbach D, Wei DQ. Different interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human alpha7 nicotinic acetylcholine receptor. Biochemistry. 2010 May 18;49(19):4169-80. doi: 10.1021/bi901999v. PubMed PMID: 20377277.

7: Feuerbach D, Lingenhoehl K, Olpe HR, Vassout A, Gentsch C, Chaperon F, Nozulak J, Enz A, Bilbe G, McAllister K, Hoyer D. The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain. Neuropharmacology. 2009 Jan;56(1):254-63. doi: 10.1016/j.neuropharm.2008.08.025. Epub 2008 Aug 28. PubMed PMID: 18793655.

8: Feuerbach D, Nozulak J, Lingenhoehl K, McAllister K, Hoyer D. JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist. Neurosci Lett. 2007 Apr 6;416(1):61-5. Epub 2007 Jan 25. PubMed PMID: 17314009.