5-NP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525886

CAS#: 4199-88-6

Description: 5-NP is a potent bactericidal agent, inhibiting Clostridium difficile and exhibiting a wide range of cytotoxicity.


Price and Availability

Size
Price

Size
Price

Size
Price

5-NP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 525886
Name: 5-NP
CAS#: 4199-88-6
Chemical Formula: C12H7N3O2
Exact Mass: 225.0538
Molecular Weight: 225.207
Elemental Analysis: C, 64.00; H, 3.13; N, 18.66; O, 14.21


Synonym: 5-NP

IUPAC/Chemical Name: 5-Nitro-1,10-phenanthroline

InChi Key: PDDBTWXLNJNICS-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H7N3O2/c16-15(17)10-7-8-3-1-5-13-11(8)12-9(10)4-2-6-14-12/h1-7H

SMILES Code: O=[N+](C1=C2C=CC=NC2=C3N=CC=CC3=C1)[O-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Liu H, Robbins M, Mehrotra A, Auerbach D, Robinson BE, Cromwell LF, Roblin DW. The Impact of Using Mid-level Providers in Face-to-Face Primary Care on Health Care Utilization. Med Care. 2017 Jan;55(1):12-18. PubMed PMID: 27367866.

2: Jevšnik M, Steyer A, Pokorn M, Mrvič T, Grosek Š, Strle F, Lusa L, Petrovec M. The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study. PLoS One. 2016 May 12;11(5):e0155555. doi: 10.1371/journal.pone.0155555. eCollection 2016. PubMed PMID: 27171141; PubMed Central PMCID: PMC4865086.

3: Munemoto M, Inagaki Y, Tanaka Y, Grammatopoulos G, Athanasou NA. Quantification of neutrophil polymorphs in infected and noninfected second-stage revision hip arthroplasties. Hip Int. 2016 Jul 25;26(4):327-30. doi: 10.5301/hipint.5000365. Epub 2016 Apr 22. PubMed PMID: 27132530.

4: ElShaer A, Mustafa S, Kasar M, Thapa S, Ghatora B, Alany RG. Nanoparticle-Laden Contact Lens for Controlled Ocular Delivery of Prednisolone: Formulation Optimization Using Statistical Experimental Design. Pharmaceutics. 2016 Apr 20;8(2). pii: E14. doi: 10.3390/pharmaceutics8020014. PubMed PMID: 27104555; PubMed Central PMCID: PMC4932477.

5: Tetaud E, Lefebvre M, M'Bang-Benet DE, Crobu L, Blancard C, Sterkers Y, Pages M, Bastien P, Merlin G. TbFlabarin, a flagellar protein of Trypanosoma brucei, highlights differences between Leishmania and Trypanosoma flagellar-targeting signals. Exp Parasitol. 2016 Jul;166:97-107. doi: 10.1016/j.exppara.2016.04.004. Epub 2016 Apr 6. PubMed PMID: 27060615.

6: Osipov A, Naziri J, Hendifar A, Dhall D, Rutgers JK, Chopra S, Li Q, Tighiouart M, Annamalai A, Nissen NN, Tuli R. Impact of margin status and lymphadenectomy on clinical outcomes in resected pancreatic adenocarcinoma: implications for adjuvant radiotherapy. J Gastrointest Oncol. 2016 Apr;7(2):239-47. doi: 10.3978/j.issn.2078-6891.2015.109. PubMed PMID: 27034792; PubMed Central PMCID: PMC4783734.

7: Guo M, Bao Q, Chen S, Cui X, Xu W, He X, Luo Y, Qi X, Huang K. Effects of neutrophils peptide-1 transgenic Chlorella ellipsoidea on the gut microbiota of male Sprague-Dawley rats, as revealed by high-throughput 16S rRNA sequencing. World J Microbiol Biotechnol. 2016 Mar;32(3):43. doi: 10.1007/s11274-015-1994-z. Epub 2016 Feb 12. PubMed PMID: 26873554.

8: Fastner G, Hauser-Kronberger C, Moder A, Reitsamer R, Zehentmayr F, Kopp P, Fussl C, Fischer T, Deutschmann H, Sedlmayer F. Survival and local control rates of triple-negative breast cancer patients treated with boost-IOERT during breast-conserving surgery. Strahlenther Onkol. 2016 Jan;192(1):1-7. doi: 10.1007/s00066-015-0895-2. Epub 2015 Sep 24. PubMed PMID: 26403912.

9: Ellens N, Hynynen K. Frequency considerations for deep ablation with high-intensity focused ultrasound: A simulation study. Med Phys. 2015 Aug;42(8):4896-10. doi: 10.1118/1.4927060. PubMed PMID: 26233216.

10: Kunda NK, Alfagih IM, Dennison SR, Somavarapu S, Merchant Z, Hutcheon GA, Saleem IY. Dry powder pulmonary delivery of cationic PGA-co-PDL nanoparticles with surface adsorbed model protein. Int J Pharm. 2015 Aug 15;492(1-2):213-22. doi: 10.1016/j.ijpharm.2015.07.015. Epub 2015 Jul 10. PubMed PMID: 26169146.

11: Zhong W, Driscoll SJ, Wu M, Wang S, Liu Z, Cha TD, Wood KB, Li G. In vivo morphological features of human lumbar discs. Medicine (Baltimore). 2014 Dec;93(28):e333. doi: 10.1097/MD.0000000000000333. PubMed PMID: 25526494; PubMed Central PMCID: PMC4603132.

12: Wood NJ, Maddocks SE, Grady HJ, Collins AM, Barbour ME. Functionalization of ethylene vinyl acetate with antimicrobial chlorhexidine hexametaphosphate nanoparticles. Int J Nanomedicine. 2014 Aug 27;9:4145-52. doi: 10.2147/IJN.S65343. eCollection 2014. PubMed PMID: 25206305; PubMed Central PMCID: PMC4157624.

13: Kobayashi T, Fujiwara K. Technical Aspects of Nominal Partitions on Accuracy of Data Mining Classification of Intestinal Microbiota - Comparison between 7 Restriction Enzymes. Biosci Microbiota Food Health. 2014;33(3):129-38. doi: 10.12938/bmfh.33.129. Epub 2014 May 16. PubMed PMID: 25032086; PubMed Central PMCID: PMC4098652.

14: Katzianer DS, Yano T, Rubin H, Zhu J. A high-throughput small-molecule screen to identify a novel chemical inhibitor of Clostridium difficile. Int J Antimicrob Agents. 2014 Jul;44(1):69-73. doi: 10.1016/j.ijantimicag.2014.03.007. Epub 2014 Apr 24. PubMed PMID: 24837414; PubMed Central PMCID: PMC4062579.

15: Tullman JA, Harmon ME, Delannoy M, Gibson W. Recovery of an HMWP/hmwBP (pUL48/pUL47) complex from virions of human cytomegalovirus: subunit interactions, oligomer composition, and deubiquitylase activity. J Virol. 2014 Aug;88(15):8256-67. doi: 10.1128/JVI.00971-14. Epub 2014 May 14. PubMed PMID: 24829352; PubMed Central PMCID: PMC4135962.

16: Sun W, Zhang K, Zhao CQ, Ding W, Yuan JJ, Sun Q, Sun XJ, Xie YZ, Li H, Zhao J. Quantitative T2 mapping to characterize the process of intervertebral disc degeneration in a rabbit model. BMC Musculoskelet Disord. 2013 Dec 18;14:357. doi: 10.1186/1471-2474-14-357. PubMed PMID: 24344686; PubMed Central PMCID: PMC3878325.

17: Xiang Z, He Y. Genome-wide prediction of vaccine targets for human herpes simplex viruses using Vaxign reverse vaccinology. BMC Bioinformatics. 2013;14 Suppl 4:S2. doi: 10.1186/1471-2105-14-S4-S2. Epub 2013 Mar 8. PubMed PMID: 23514126; PubMed Central PMCID: PMC3599071.

18: Novotny SR, Wallace K, Heath J, Moseley J, Dhillon P, Weimer A, Wallukat G, Herse F, Wenzel K, Martin JN Jr, Dechend R, Lamarca B. Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats. Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1197-201. doi: 10.1152/ajpregu.00623.2011. Epub 2012 Mar 28. PubMed PMID: 22461177; PubMed Central PMCID: PMC3362148.

19: Kameda T, Akiyama A, Toriba A, Tang N, Hayakawa K. Atmospheric formation of hydroxynitropyrenes from a photochemical reaction of particle-associated 1-nitropyrene. Environ Sci Technol. 2011 Apr 15;45(8):3325-32. doi: 10.1021/es1042172. Epub 2011 Mar 15. PubMed PMID: 21405083.

20: Schmitt PT, Ray G, Schmitt AP. The C-terminal end of parainfluenza virus 5 NP protein is important for virus-like particle production and M-NP protein interaction. J Virol. 2010 Dec;84(24):12810-23. doi: 10.1128/JVI.01885-10. Epub 2010 Oct 13. PubMed PMID: 20943976; PubMed Central PMCID: PMC3004301.