ABL/KIT-155

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525883

CAS#: N/A

Description: ABL/KIT-155 is a novel potent type II ABL/c-KIT dual kinase inhibitor.


Price and Availability

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ABL/KIT-155 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525883
Name: ABL/KIT-155
CAS#: N/A
Chemical Formula: C32H36F3N5O3
Exact Mass: 595.277
Molecular Weight: 595.6672
Elemental Analysis: C, 64.52; H, 6.09; F, 9.57; N, 11.76; O, 8.06


Synonym: ABL/KIT-155

IUPAC/Chemical Name: 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamideis a novel potent type II ABL/c-KIT dual kinase inhibitor

InChi Key: FKVQLDQNVYEANX-UHFFFAOYSA-N

InChi Code: InChI=1S/C32H36F3N5O3/c1-22-5-6-23(18-29(22)43-27-9-12-40(13-10-27)31(42)24-4-3-11-36-20-24)30(41)37-26-8-7-25(28(19-26)32(33,34)35)21-39-16-14-38(2)15-17-39/h3-8,11,18-20,27H,9-10,12-17,21H2,1-2H3,(H,37,41)

SMILES Code: O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(OC4CCN(C(C5=CN=CC=C5)=O)CC4)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wang Q, Liu F, Wang B, Zou F, Qi Z, Chen C, Yu K, Hu C, Qi S, Wang W, Hu Z, Liu J, Wang W, Wang L, Liang Q, Zhang S, Ren T, Liu Q, Liu J. Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-n icotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding. J Med Chem. 2017 Jan 12;60(1):273-289. doi: 10.1021/acs.jmedchem.6b01290. Epub 2016 Dec 14. PubMed PMID: 27966954.