WAY-213613

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532964

CAS#: 868359-05-1

Description: WAY-213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). WAY-213613 exhibits no activity towards ionotropic and metabotropic glutamate receptors.


Price and Availability

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WAY-213613 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532964
Name: WAY-213613
CAS#: 868359-05-1
Chemical Formula: C16H13BrF2N2O4
Exact Mass: 414.0027
Molecular Weight: 415.19
Elemental Analysis: C, 46.29; H, 3.16; Br, 19.25; F, 9.15; N, 6.75; O, 15.41


Synonym: WAY-213613; WAY 213613; WAY213613.

IUPAC/Chemical Name: (2S)-2-amino-3-{[4-(2-bromo-4,5-difluorophenoxy)phenyl]carbamoyl}propanoic acid

InChi Key: BNYDDAAZMBUFRG-ZDUSSCGKSA-N

InChi Code: InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1

SMILES Code: O=C(O)[C@@H](N)CC(NC1=CC=C(OC2=CC(F)=C(F)C=C2Br)C=C1)=O


Technical Data

Appearance:
White to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P. Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells. Neuroscience. 2009 Jul 7;161(3):794-805. doi: 10.1016/j.neuroscience.2009.04.017. Epub 2009 Apr 11. PubMed PMID: 19364521.

2: Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, Lin S, Greenfield A, Grosanu C, Fan K, Petroski R, Williams J, Foster A, Butera J. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. PubMed PMID: 16014807.