WAY170523

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532960

CAS#: 307002-73-9

Description: WAY170523 is a selective and potent inhibitor of MMP-13(IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively). MMPs (matrix metalloproteinases) are commonly known to be involved in the degradation of various extracellular matrix proteins.


Price and Availability

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Price

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WAY170523 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532960
Name: WAY170523
CAS#: 307002-73-9
Chemical Formula: C33H31N3O7S
Exact Mass: 613.1883
Molecular Weight: 613.69
Elemental Analysis: C, 64.59; H, 5.09; N, 6.85; O, 18.25; S, 5.22


Synonym: WAY170523; WAY-170523; WAY 170523

IUPAC/Chemical Name: N-[2-(4-{benzyl[2-(hydroxycarbamoyl)-4,6-dimethylphenyl]sulfamoyl}phenoxy)ethyl]-1-benzofuran-2-carboxamide

InChi Key: FARMEEAGJWMFSZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H31N3O7S/c1-22-18-23(2)31(28(19-22)32(37)35-39)36(21-24-8-4-3-5-9-24)44(40,41)27-14-12-26(13-15-27)42-17-16-34-33(38)30-20-25-10-6-7-11-29(25)43-30/h3-15,18-20,39H,16-17,21H2,1-2H3,(H,34,38)(H,35,37)

SMILES Code: O=C(C(O1)=CC2=C1C=CC=C2)NCCOC3=CC=C(S(=O)(N(CC4=CC=CC=C4)C5=C(C)C=C(C)C=C5C(NO)=O)=O)C=C3


Technical Data

Appearance:
White to beige solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1. Jaffré et al (2012) ß-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 125 2993. PMID: 22610965.