YF-452

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525861

CAS#: 1951466-83-3

Description: YF-452 is a novel inhibitor of tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling.


Price and Availability

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YF-452 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525861
Name: YF-452
CAS#: 1951466-83-3
Chemical Formula: C24H26BrN3O
Exact Mass: 451.1259
Molecular Weight: 452.396
Elemental Analysis: C, 63.72; H, 5.79; Br, 17.66; N, 9.29; O, 3.54


Synonym: YF-452

IUPAC/Chemical Name: N-(N-Pyrrolidylacetyl)-9-(4-bromobenzyl)-1,3,4,9-tetrahydro-ß-carboline

InChi Key: WIRUYQFUVBBWPT-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H26BrN3O/c25-19-9-7-18(8-10-19)15-28-22-6-2-1-5-20(22)21-11-14-27(16-23(21)28)24(29)17-26-12-3-4-13-26/h1-2,5-10H,3-4,11-17H2

SMILES Code: BrC(C=C1)=CC=C1CN(C2=C3CCN(C(CN4CCCC4)=O)C2)C5=C3C=CC=C5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Liu Y, He Y, Yang F, Cong X, Wang J, Peng S, Gao D, Wang W, Lan L, Ying X, Liu M, Chen Y, Yi Z. A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling. Sci China Life Sci. 2017 Feb;60(2):202-214. doi: 10.1007/s11427-016-0369-6. Epub 2017 Feb 13. PubMed PMID: 28194552.