VUF5574
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MedKoo CAT#: 532953

CAS#: 280570-45-8

Description: VUF5574 is a potent, selective, competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM). VUF5574 displays ≥ 2500-fold selectivity over A1 and A2A receptors.


Chemical Structure

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VUF5574
CAS# 280570-45-8

Theoretical Analysis

MedKoo Cat#: 532953
Name: VUF5574
CAS#: 280570-45-8
Chemical Formula: C21H17N5O2
Exact Mass: 371.14
Molecular Weight: 371.400
Elemental Analysis: C, 67.91; H, 4.61; N, 18.86; O, 8.62

Price and Availability

Size Price Availability Quantity
1mg USD 205 2 Weeks
5mg USD 385 2 Weeks
10mg USD 575 2 Weeks
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Synonym: VUF5574, VUF 5574, VUF-5574

IUPAC/Chemical Name: 3-(2-methoxyphenyl)-1-(2-pyridin-3-ylquinazolin-4-yl)urea

InChi Key: YRAFEJSZTVWUMD-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H17N5O2/c1-28-18-11-5-4-10-17(18)24-21(27)26-20-15-8-2-3-9-16(15)23-19(25-20)14-7-6-12-22-13-14/h2-13H,1H3,(H2,23,24,25,26,27)

SMILES Code: O=C(NC1=CC=CC=C1OC)NC2=C3C=CC=CC3=NC(C4=CC=CN=C4)=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 371.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456. PMID: 11121831.

2. van Muijlwijk-Koezen et al (2000) Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J.Med.Chem. 43 2227. PMID: 10841801.