VU0463841

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532948

CAS#: 1439095-16-5

Description: VU0463841 is a negative allosteric modulators of mGlu5.

Chemical Structure

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VU0463841
CAS# 1439095-16-5
Instruction

Theoretical Analysis

MedKoo Cat#: 532948
Name: VU0463841
CAS#: 1439095-16-5
Chemical Formula: C13H8ClFN4O
Exact Mass: 290.04
Molecular Weight: 290.680
Elemental Analysis: C, 53.72; H, 2.77; Cl, 12.20; F, 6.54; N, 19.27; O, 5.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: VU0463841, VU-0463841, VU 0463841

IUPAC/Chemical Name: 1-(5-chloropyridin-2-yl)-3-(3-cyano-5-fluorophenyl)urea

InChi Key: KDANLHLWAYNCMV-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H8ClFN4O/c14-9-1-2-12(17-7-9)19-13(20)18-11-4-8(6-16)3-10(15)5-11/h1-5,7H,(H2,17,18,19,20)

SMILES Code: O=C(NC1=CC(F)=CC(C#N)=C1)NC2=NC=C(Cl)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 290.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Amato RJ, Felts AS, Rodriguez AL, Venable DF, Morrison RD, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Jones CK, Emmitte KA. Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. ACS Chem Neurosci. 2013 Aug 21;4(8):1217-28. doi: 10.1021/cn400070k. Epub 2013 May 29. PubMed PMID: 23682684; PubMed Central PMCID: PMC3750677.