UCM 765

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532866

CAS#: 944284-77-9

Description: UCM 765 is a melatonin MT(2) receptor partial agonist.


Chemical Structure

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UCM 765
CAS# 944284-77-9

Theoretical Analysis

MedKoo Cat#: 532866
Name: UCM 765
CAS#: 944284-77-9
Chemical Formula: C17H20N2O2
Exact Mass: 284.15
Molecular Weight: 284.360
Elemental Analysis: C, 71.81; H, 7.09; N, 9.85; O, 11.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UCM 765, UCM765, UCM-765

IUPAC/Chemical Name: N-[2-[(4-methoxyphenyl)-phenylamino]ethyl]acetamide

InChi Key: PWTCGLHUMIIRML-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N2O2/c1-14(20)18-12-13-19(15-6-4-3-5-7-15)16-8-10-17(21-2)11-9-16/h3-11H,12-13H2,1-2H3,(H,18,20)

SMILES Code: CC(NCCN(C1=CC=C(OC)C=C1)C2=CC=CC=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 284.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: López-Canul M, Comai S, Domínguez-López S, Granados-Soto V, Gobbi G. Antinociceptive properties of selective MT(2) melatonin receptor partial agonists. Eur J Pharmacol. 2015 Oct 5;764:424-32. doi: 10.1016/j.ejphar.2015.07.010. Epub 2015 Jul 7. PubMed PMID: 26162699.

2: Ochoa-Sanchez R, Rainer Q, Comai S, Spadoni G, Bedini A, Rivara S, Fraschini F, Mor M, Tarzia G, Gobbi G. Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Dec 3;39(2):318-25. doi: 10.1016/j.pnpbp.2012.07.003. Epub 2012 Jul 10. PubMed PMID: 22789661.

3: Harrington M. Specific melatonin receptor promotes a deeper sleep. Lab Anim (NY). 2012 Jan 20;41(2):31. doi: 10.1038/laban0212-31b. PubMed PMID: 22261877.

4: Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G, Rivara S, Bedini A, Angeloni D, Fraschini F, Mor M, Tarzia G, Descarries L, Gobbi G. Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand. J Neurosci. 2011 Dec 14;31(50):18439-52. doi: 10.1523/JNEUROSCI.2676-11.2011. PubMed PMID: 22171046.

5: Rivara S, Vacondio F, Fioni A, Silva C, Carmi C, Mor M, Lucini V, Pannacci M, Caronno A, Scaglione F, Gobbi G, Spadoni G, Bedini A, Orlando P, Lucarini S, Tarzia G. N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. ChemMedChem. 2009 Oct;4(10):1746-55. doi: 10.1002/cmdc.200900240. PubMed PMID: 19728346.