Bromhexine HCl | CAS#611-75-6 | CAS#3572-43-8 | Synthetic Vasicine Derivative

Bromhexine HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540051

CAS#: 611-75-6 (HCl)

Description: Bromhexine HCl is a synthetic vasicine derivative used to treat mucus-related respiratory disorders. It increases production of serous mucus, decrease mucus viscosity and helps cilia transport mucus out of the lungs.

Chemical Structure

Bromhexine HCl

CAS# 611-75-6 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 540051
Name: Bromhexine HCl
CAS#: 611-75-6 (HCl)
Chemical Formula: C14H21Br2ClN2
Exact Mass: 0.00
Molecular Weight: 412.590
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 40.76; H, 5.13; Br, 38.73; Cl, 8.59; N, 6.79

Price and Availability

Size	Price	Availability	Quantity
25g	USD 275	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 611-75-6 (HCl) 3572-43-8 (free)

Synonym: Bromessina; Broncokin; Lisomucin; NA 274; NA-274; NA274

IUPAC/Chemical Name: 2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

InChi Key: UCDKONUHZNTQPY-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H

SMILES Code: CN(C1CCCCC1)CC2=CC(Br)=CC(Br)=C2N.[H]Cl

Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 412.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Abdel-Ghani NT, Rizk MS, Mostafa M. Extractive determination of ephedrine hydrochloride and bromhexine hydrochloride in pure solutions, pharmaceutical dosage form and urine samples. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Jul;111:131-41. doi: 10.1016/j.saa.2013.03.038. Epub 2013 Mar 21. PubMed PMID: 23624039.

2: Tantishaiyakul V, Poeaknapo C, Sribun P, Sirisuppanon K. Simultaneous determination of dextromethorphan HBr and bromhexine HCl in tablets by first-derivative spectrophotometry. J Pharm Biomed Anal. 1998 Jun;17(2):237-43. PubMed PMID: 9638576.

3: Kukita T, Furuuchi S, Nemoto M, Yoshida T. Interaction between polyethylene films and bromhexine HCl in solid dosage form. V. Effect of packaging materials on the sorption of bromhexine HCl. Chem Pharm Bull (Tokyo). 1992 Nov;40(11):3110-2. PubMed PMID: 1477930.

4: Dube AK, Kumar MS. Biotransformation of bromhexine by Cunninghamella elegans, C. echinulata and C. blakesleeana. Braz J Microbiol. 2017 Apr - Jun;48(2):259-267. doi: 10.1016/j.bjm.2016.11.003. Epub 2016 Dec 5. PubMed PMID: 27988088.

5: Schubert MA, Müller-Goymann CC. Solubilization of bromhexine hydrochloride in aqueous lecithin dispersions. Physicochemical characterization of interactions between drug and carrier. Pharmazie. 2001 Sep;56(9):734-7. PubMed PMID: 11593995.

6: Kukita T, Yamaguchi A, Okamoto A, Nemoto M. Interaction between polyethylene films and bromhexine HCl in solid dosage form. IV. Prevention of the sorption by addition of magnesium aluminum silicate. Chem Pharm Bull (Tokyo). 1992 May;40(5):1257-60. PubMed PMID: 1394643.

7: Kukita T, Yamaguchi A, Okamoto A, Nemoto M, Yamaguchi H, Yamamoto K, Nakai Y. [Interaction between polyethylene films and bromhexine HCl in solid dosage forms. I. Effects of moisture contents in the solid dosage forms on the sorption of the drug]. Yakugaku Zasshi. 1989 Dec;109(12):943-8. Japanese. PubMed PMID: 2630637.

8: Aggarwal AK, Gupta M. Solubility and solution stability studies of different amino acid prodrugs of bromhexine. Drug Dev Ind Pharm. 2012 Nov;38(11):1319-27. Epub 2012 Jan 28. PubMed PMID: 22283553.

9: Stojanov M, Nielsen HM, Larsen KL. Cyclodextrins: Efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems. Int J Pharm. 2012 Jan 17;422(1-2):349-55. doi: 10.1016/j.ijpharm.2011.10.023. Epub 2011 Oct 17. PubMed PMID: 22027391.

10: Azodi-Deilami S, Abdouss M, Javanbakht M. The syntheses and characterization of molecularly imprinted polymers for the controlled release of bromhexine. Appl Biochem Biotechnol. 2011 May;164(2):133-47. doi: 10.1007/s12010-010-9121-y. Epub 2010 Nov 14. PubMed PMID: 21076945.

11: Vide J, Moreira C, Cunha AP, Baldaia H, Magina S, Azevedo F. Generalized Bullous Fixed Drug Eruption due to Bromhexine. Dermatol Online J. 2016 Jul 15;22(7). pii: 13030/qt7nt074w4. PubMed PMID: 27617726.

12: Liu J, Chen X, Hu Y, Cheng G, Zhong D. Quantification of the major metabolites of bromhexine in human plasma using RRLC-MS/MS and its application to pharmacokinetics. J Pharm Biomed Anal. 2010 Apr 6;51(5):1134-41. doi: 10.1016/j.jpba.2009.11.024. Epub 2009 Dec 1. PubMed PMID: 20031363.

13: Javanbakht M, Namjumanesh MH, Akbari-Adergani B. Molecularly imprinted solid-phase extraction for the selective determination of bromhexine in human serum and urine with high performance liquid chromatography. Talanta. 2009 Nov 15;80(1):133-8. doi: 10.1016/j.talanta.2009.06.033. Epub 2009 Jun 21. PubMed PMID: 19782202.

14: Prabhu Shankar S, Chandrashekharan S, Bolmall CS, Baliga V. Efficacy, safety and tolerability of salbutamol + guaiphenesin + bromhexine (Ascoril) expectorant versus expectorants containing salbutamol and either guaiphenesin or bromhexine in productive cough: a randomised controlled comparative study. J Indian Med Assoc. 2010 May;108(5):313-4, 316-8, 320. PubMed PMID: 21121410.

15: Ambroxol, bromhexine: anaphylactic reactions. Prescrire Int. 2015 Apr;24(159):98. PubMed PMID: 25941704.

16: Zhang W, Feng F, Wang Y. Bioequivalence study of bromhexine by liquid chromatography-electrospray ionization-mass spectrometry after oral administration of bromhexine hydrochloride tablets. J Pharm Biomed Anal. 2008 Dec 1;48(4):1206-10. doi: 10.1016/j.jpba.2008.08.017. Epub 2008 Aug 23. PubMed PMID: 18835672.

17: Venhuis BJ, Weda M, de Kaste D, Lamme EK. On the formation of bromhexine impurity E and its chromatographic behaviour. Pharmeur Bio Sci Notes. 2012 Apr;2012:135-41. PubMed PMID: 23327897.

18: Zanasi A, Mazzolini M, Kantar A. A reappraisal of the mucoactive activity and clinical efficacy of bromhexine. Multidiscip Respir Med. 2017 Mar 20;12:7. doi: 10.1186/s40248-017-0088-1. eCollection 2017. Review. PubMed PMID: 28331610; PubMed Central PMCID: PMC5359817.

19: Jiang Q, Nie F, Lu J. Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent. Luminescence. 2008 Jan-Feb;23(1):32-6. doi: 10.1002/bio.1013. PubMed PMID: 18175361.

20: Matts SG. A comparative trial of bromhexine HCl and oxytetracycline in acute and chronic bronchitis. Br J Clin Pract. 1974 Dec;28(12):403-5. PubMed PMID: 4617590.

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