UCL-1848 trifluoroacetate salt

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532860

CAS#: 201147-53-7

Description: UCL-1848 trifluoroacetate salt is a selective Ca2+-activated, SK potassium channel blocker.


Chemical Structure

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UCL-1848 trifluoroacetate salt
CAS# 201147-53-7

Theoretical Analysis

MedKoo Cat#: 532860
Name: UCL-1848 trifluoroacetate salt
CAS#: 201147-53-7
Chemical Formula: C28H34N42+
Exact Mass: 426.28
Molecular Weight: 426.610
Elemental Analysis: C, 78.83; H, 8.03; N, 13.13

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UCL1848, UCL-1848, UCL 1848, UCL-1848 trifluoroacetate salt

IUPAC/Chemical Name: 8,14-Diaza-1,7(1,4)-diquinolinacyclotetradecaphane trifluoroacetate salt

InChi Key: IOXVWOJJNCBJBX-XDHTVYJESA-P

InChi Code: InChI=1S/C28H32N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22H,1-2,7-10,17-20H2/p+2/b29-25+,30-26+

SMILES Code: c1(NCCCCCNc2c(cccc3)c3[n+]4cc2)c5ccccc5[n+](CCCCC4)cc1

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 426.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Abdullaev IF, Rudkouskaya A, Mongin AA, Kuo YH. Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation. PLoS One. 2010 Aug 20;5(8):e12304. doi: 10.1371/journal.pone.0012304. PubMed PMID: 20808839; PubMed Central PMCID: PMC2924897.

2: Lopez de Armentia M, Sah P. Firing properties and connectivity of neurons in the rat lateral central nucleus of the amygdala. J Neurophysiol. 2004 Sep;92(3):1285-94. Epub 2004 May 5. PubMed PMID: 15128752.

3: Faber ES, Sah P. Physiological role of calcium-activated potassium currents in the rat lateral amygdala. J Neurosci. 2002 Mar 1;22(5):1618-28. PubMed PMID: 11880492.

4: Shah M, Haylett DG. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30. PubMed PMID: 10683185; PubMed Central PMCID: PMC1571896.