UCCF-853

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532859

CAS#: 625458-06-2

Description: UCCF-853 is an activator of the CFTR Cl- channel which may be useful for therapy of cystic fibrosis.


Price and Availability

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Price

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UCCF-853 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532859
Name: UCCF-853
CAS#: 625458-06-2
Chemical Formula: C14H8ClF3N2O
Exact Mass: 312.0277
Molecular Weight: 312.68
Elemental Analysis: C, 53.78; H, 2.58; Cl, 11.34; F, 18.23; N, 8.96; O, 5.12


Synonym: UCCF-853, UCCF 853, UCCF853

IUPAC/Chemical Name: 1-(3-chlorophenyl)-5-(trifluoromethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one

InChi Key: NMPJFFWYEIIGFW-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H8ClF3N2O/c15-9-2-1-3-10(7-9)20-12-5-4-8(14(16,17)18)6-11(12)19-13(20)21/h1-7H,(H,19,21)

SMILES Code: O=C1N(C2=CC=CC(Cl)=C2)C3=CC=C(C(F)(F)F)C=C3N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L180-8. Epub 2003 Mar 21. PubMed PMID: 12651632.