U46619

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532848

CAS#: 56985-40-1

Description: U46619 is a PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). U46619 potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. It activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.


Price and Availability

Size
Price

Size
Price

Size
Price

U46619 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 532848
Name: U46619
CAS#: 56985-40-1
Chemical Formula: C21H34O4
Exact Mass: 350.2457
Molecular Weight: 350.5
Elemental Analysis: C, 71.96; H, 9.78; O, 18.26


Synonym: U46619, U-46619, U 46619

IUPAC/Chemical Name: (Z)-7-[(1S,4R,5R,6S)-5-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acid

InChi Key: LQANGKSBLPMBTJ-BRSNVKEHSA-N

InChi Code: InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1

SMILES Code: O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)[C@]2([H])OC[C@@]1([H])C2


Technical Data

Appearance:
Clear oil

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1. Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor. Mol.Pharmacol. 61 817. PMID: 11901221.

2. Morinelli et al (1987) Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035. PMID: 3688248.