TAK-637

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532811

CAS#: 217185-75-6

Description: TAK-637 is a tachykinin 1 (NK1) receptor antagonist, and identified as a clinical candidate for the treatment of bladder function disorder.


Chemical Structure

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TAK-637
CAS# 217185-75-6

Theoretical Analysis

MedKoo Cat#: 532811
Name: TAK-637
CAS#: 217185-75-6
Chemical Formula: C30H25F6N3O2
Exact Mass: 573.19
Molecular Weight: 573.540
Elemental Analysis: C, 62.83; H, 4.39; F, 19.87; N, 7.33; O, 5.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: TAK-637, TAK 637, TAK637

IUPAC/Chemical Name: (9R)-7-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-methyl-5-(4-methylphenyl)-8,9,10,11-tetrahydro-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione

InChi Key: LDXQLWNPGRANTO-GOSISDBHSA-N

InChi Code: InChI=1S/C30H25F6N3O2/c1-17-5-7-20(8-6-17)24-23-4-3-10-37-25(23)27(40)39-11-9-18(2)15-38(28(41)26(24)39)16-19-12-21(29(31,32)33)14-22(13-19)30(34,35)36/h3-8,10,12-14,18H,9,11,15-16H2,1-2H3/t18-/m1/s1

SMILES Code: O=C1N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C[C@H](C)CCN3C1=C(C4=CC=C(C)C=C4)C5=C(N=CC=C5)C3=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 573.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tarui N, Ikeura Y, Natsugari H, Nakahama K. Microbial synthesis of three metabolites of a tachykinin receptor antagonist, TAK-637. J Biosci Bioeng. 2001;92(3):285-7. PubMed PMID: 16233097.

2: Venkova K, Greenwood-Van Meerveld B. Effects of TAK-637 on NK(1) receptor-mediated mechanisms regulating colonic secretion. Toxicol Appl Pharmacol. 2004 Apr 15;196(2):215-22. PubMed PMID: 15081268.

3: Furness JB. TAK-637. Takeda. Curr Opin Investig Drugs. 2001 Oct;2(10):1437-40. Review. PubMed PMID: 11890361.

4: Venkova K, Sutkowski-Markmann DM, Greenwood-Van Meerveld B. Peripheral activity of a new NK1 receptor antagonist TAK-637 in the gastrointestinal tract. J Pharmacol Exp Ther. 2002 Mar;300(3):1046-52. PubMed PMID: 11861814.

5: Kamo I, Doi T. Effect of TAK-637, a tachykinin NK1-receptor antagonist, on lower urinary tract function in cats. Jpn J Pharmacol. 2001 Jun;86(2):165-9. PubMed PMID: 11459118.

6: Okano S, Nagaya H, Ikeura Y, Natsugari H, Inatomi N. Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo. J Pharmacol Exp Ther. 2001 Aug;298(2):559-64. PubMed PMID: 11454917.

7: Kamo I, Imai S, Okanishi S, Doi T. Possible site of action of TAK-637, a tachykinin NK(1) receptor antagonist, on the micturition reflex in guinea pigs. Eur J Pharmacol. 2000 Aug 4;401(2):235-40. PubMed PMID: 10924932.

8: Doi T, Kamo I, Imai S, Okanishi S, Ikeura Y, Natsugari H. Effects of TAK-637, a tachykinin receptor antagonist, on the micturition reflex in guinea pigs. Eur J Pharmacol. 2000 May 3;395(3):241-6. PubMed PMID: 10812055.

9: Doi T, Kamo I, Imai S, Okanishi S, Ishimaru T, Ikeura Y, Natsugari H. Effects of TAK-637, a tachykinin receptor antagonist, on lower urinary tract function in the guinea pig. Eur J Pharmacol. 1999 Nov 3;383(3):297-303. PubMed PMID: 10594323.