B-I09

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525366

CAS#: 1607803-67-7

Description: B-I09 is a novel cell permeable IRE-1 RNase inhibitor, blocking IRE-1/XBP1 pathway.


Price and Availability

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Price

Size
Price

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Price

B-I09 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525366
Name: B-I09
CAS#: 1607803-67-7
Chemical Formula: C16H17NO5
Exact Mass: 303.1107
Molecular Weight: 303.314
Elemental Analysis: C, 63.36; H, 5.65; N, 4.62; O, 26.37


Synonym: B-I09

IUPAC/Chemical Name: 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one

InChi Key: UYYMWNUDIOPESF-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17NO5/c18-12-3-2-10-9-4-5-17-8-11(9)15(19)22-14(10)13(12)16-20-6-1-7-21-16/h2-3,16-18H,1,4-8H2

SMILES Code: O=C1OC2=C(C3OCCCO3)C(O)=CC=C2C4=C1CNCC4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tang CH, Ranatunga S, Kriss CL, Cubitt CL, Tao J, Pinilla-Ibarz JA, Del Valle JR, Hu CC. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014 Jun;124(6):2585-98. doi: 10.1172/JCI73448. Epub 2014 May 8. PubMed PMID: 24812669; PubMed Central PMCID: PMC4038575.