T-226296

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532805

CAS#: 331758-35-1

Description: T-226296 is a melanin concentrating hormone receptor 1 (MCHR1) antagonist.


Price and Availability

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Price

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T-226296 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532805
Name: T-226296
CAS#: 331758-35-1
Chemical Formula: C26H27FN2O
Exact Mass: 402.2107
Molecular Weight: 402.51
Elemental Analysis: C, 77.58; H, 6.76; F, 4.72; N, 6.96; O, 3.97


Synonym: T-226296, T 226296, T226296

IUPAC/Chemical Name: N-[6-(dimethylaminomethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamide

InChi Key: GXAQELJVODWLDD-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H27FN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30)

SMILES Code: O=C(NC1=CC=C2CC(CN(C)C)CCC2=C1)C3=CC=C(C4=CC=C(F)C=C4)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Högberg T, Frimurer TM, Sasmal PK. Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment? Bioorg Med Chem Lett. 2012 Oct 1;22(19):6039-47. doi: 10.1016/j.bmcl.2012.08.025. Epub 2012 Aug 19. PubMed PMID: 22954736.

2: Saito Y, Maruyama K. Identification of melanin-concentrating hormone receptor and its impact on drug discovery. J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):761-8. Review. PubMed PMID: 16902961.

3: Basso AM, Bratcher NA, Gallagher KB, Cowart MD, Zhao C, Sun M, Esbenshade TA, Brune ME, Fox GB, Schmidt M, Collins CA, Souers AJ, Iyengar R, Vasudevan A, Kym PR, Hancock AA, Rueter LE. Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20. Epub 2006 May 6. PubMed PMID: 16765941.

4: Kowalski TJ, Farley C, Cohen-Williams ME, Varty G, Spar BD. Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size. Eur J Pharmacol. 2004 Aug 16;497(1):41-7. PubMed PMID: 15321733.

5: Vitale RM, Pedone C, De Benedetti PG, Fanelli F. Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations. Proteins. 2004 Aug 15;56(3):430-48. PubMed PMID: 15229878.

6: Gao X, Hsu CK, Heinz LJ, Morin J, Shi Y, Shukla NK, Smiley DL, Xu J, Zhong B, Slieker LJ. Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal Biochem. 2004 May 15;328(2):187-95. PubMed PMID: 15113696.

7: Takekawa S, Asami A, Ishihara Y, Terauchi J, Kato K, Shimomura Y, Mori M, Murakoshi H, Kato K, Suzuki N, Nishimura O, Fujino M. T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur J Pharmacol. 2002 Mar 8;438(3):129-35. PubMed PMID: 11909603.