Bestatin HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540043

CAS#: 65391-42-6

Description: Bestatin HCl is an amniopeptidase(N/CDl3) inhibitor. It induces differentiation of actue promyelocytic leukemia cells, enhances proliferation of hone marrow macrophage progenitor cells, and inhibits catabolism of opioid endopeptides.


Price and Availability

Size
Price

5mg
USD 150
Size
Price

10mg
USD 200
Size
Price

50mg
USD 650

Bestatin HCl purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 540043
Name: Bestatin HCl
CAS#: 65391-42-6
Chemical Formula: C16H25ClN2O4
Exact Mass: 344.1503
Molecular Weight: 344.83
Elemental Analysis: C, 55.73; H, 7.31; Cl, 10.28; N, 8.12; O, 18.56


Synonym: Bestatin HCl; HY-B0134A; ZX-AFC000603; CCG-207863; CS-1911; HYB0134A; ZXAFC000603; CCG207863; CS1911; HY B0134A; ZX AFC000603; CCG 207863; CS 1911

IUPAC/Chemical Name: ((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine hydrochloride

InChi Key: XGDFITZJGKUSDK-UDYGKFQRSA-N

InChi Code: InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1

SMILES Code: CC(C)C[C@H](NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O)C(O)=O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Botbol V, Scornik OA. Measurement of muscle protein degradation in live mice by accumulation of bestatin-induced peptides. Am J Physiol. 1997 Dec;273(6 Pt 1):E1149-57. PubMed PMID: 9435531.

2: Lwalaba D, Weidlich S, Hoffmann KH, Woodring J. Exogenous and endogenous protease inhibitors in the gut of the fall armyworm larvae, Spodoptera frugiperda. Arch Insect Biochem Physiol. 2010 Jun;74(2):114-26. doi: 10.1002/arch.20366. PubMed PMID: 20513059.

3: Süss J, Egerer R, Stelzner A. A phagocytosis capacity assay: parallel measurement of the phagocytosis and the intracellular killing in granulocytes and the influence of some substances on these processes. Zentralbl Bakteriol. 1991 Jun;275(2):248-55. PubMed PMID: 1930577.

4: Machida M, Hayashi M, Awazu S. The effects of absorption enhancers on the pulmonary absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats. Biol Pharm Bull. 2000 Jan;23(1):84-6. PubMed PMID: 10706417.

5: Gee NS, Kenny AJ. Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W. Biochem J. 1987 Aug 15;246(1):97-102. PubMed PMID: 2890346; PubMed Central PMCID: PMC1148244.