YH250

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525227

CAS#: N/A

Description: YH250 is a novel specific antagonist of p300/catenin interaction, stimulating hematopoiesis in lethally or sublethally irradiated mice.


Price and Availability

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YH250 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525227
Name: YH250
CAS#: N/A
Chemical Formula: C33H38Cl2N6O6
Exact Mass: 684.223
Molecular Weight: 685.603
Elemental Analysis: C, 57.81; H, 5.59; Cl, 10.34; N, 12.26; O, 14.00


Synonym: YH250

IUPAC/Chemical Name: 9a(S)-8-(3,5-Dichloro-2-dimethylamino-benzyl)-6(S)-(4-hydroxy-benzyl)-2-methyl-4,7-dioxo-hexahydro-pyrazino[2,1-c][1,2,4]triazine-1-carboxylic acid 2,3-dimethoxy-benzylamide

InChi Key: FQDWMGBGVNSQFB-RXBHZZDJSA-N

InChi Code: InChI=1S/C33H38Cl2N6O6/c1-37(2)31-22(13-23(34)15-25(31)35)14-26(20-9-11-24(42)12-10-20)39-17-28-40(19-30(39)44)29(43)18-38(3)41(28)33(45)36-16-21-7-6-8-27(46-4)32(21)47-5/h6-13,15,26,28,42H,14,16-19H2,1-5H3,(H,36,45)/t26?,28-/m0/s1

SMILES Code: O=C(N([C@](CN1C(CC2=CC(Cl)=CC(Cl)=C2N(C)C)C3=CC=C(O)C=C3)([H])N4CC1=O)N(C)CC4=O)NCC5=CC=CC(OC)=C5OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zhao Y, Wu K, Nguyen C, Smbatyan G, Melendez E, Higuchi Y, Chen Y, Kahn M. Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation. PLoS One. 2017 May 9;12(5):e0177245. doi: 10.1371/journal.pone.0177245. eCollection 2017. PubMed PMID: 28486541; PubMed Central PMCID: PMC5423697.