SCH 221510
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MedKoo CAT#: 532692

CAS#: 322473-89-2

Description: SCH 221510 is a potent and selective nociceptin opioid receptor (NOP) agonist (EC50 values are 12, 693, 683 and 8071 nM, and Ki values are 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors respectively). SCH221510 exhibits anxiolytic-like activity at doses that have no effect on overt behaviors such as locomotion in vivo.


Chemical Structure

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SCH 221510
CAS# 322473-89-2

Theoretical Analysis

MedKoo Cat#: 532692
Name: SCH 221510
CAS#: 322473-89-2
Chemical Formula: C28H31NO
Exact Mass: 397.24
Molecular Weight: 397.560
Elemental Analysis: C, 84.59; H, 7.86; N, 3.52; O, 4.02

Price and Availability

Size Price Availability Quantity
10mg USD 405 2 Weeks
50mg USD 1395 2 Weeks
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Synonym: SCH221510; SCH 221510; SCH-221510.

IUPAC/Chemical Name: 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol

InChi Key: LOSJNRBXNQTUNT-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3

SMILES Code: OC1(C2=CC=CC=C2)CC(N3C(C4=CC=CC=C4C)C5=CC=CC=C5C)CCC3C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: SCH 221510 is an NOP agonist (EC50 values are 12, 693, 683 and 8071 nM, and Ki values are 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors respectively).
In vitro activity: To be determined
In vivo activity: SCH 221510 may have potential in the treatment of drug addiction. When given to rodents, SCH 221510 did not prompt the same response to self-administer the drug as the traditional opioid remifentanil. Instead, SCH 221510 curbed the desire for remifentanil, similar to naltrexone. Unlike naltrexone, SCH221510 reduced the rodents' motivation to seek non-drug rewards, like sucrose pellets. Reference: Eur J Pharmacol. 2014 Dec 15;745:182-9. https://pubmed.ncbi.nlm.nih.gov/25446568/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.8 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 397.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Sukhtankar DD, Lagorio CH, Ko MC. Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats. Eur J Pharmacol. 2014 Dec 15;745:182-9. doi: 10.1016/j.ejphar.2014.10.029. Epub 2014 Oct 29. PMID: 25446568; PMCID: PMC4259829. 2. Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Sałaga M, Storr M, Kordek R, Małecka-Panas E, Krajewska WM, Fichna J. Anti-inflammatory and antinociceptive action of an orally available nociceptin receptor agonist SCH 221510 in a mouse model of inflammatory bowel diseases. J Pharmacol Exp Ther. 2014 Mar;348(3):401-9. doi: 10.1124/jpet.113.209825. Epub 2013 Dec 17. PMID: 24345466.
In vitro protocol: To be determined
In vivo protocol: 1. Sukhtankar DD, Lagorio CH, Ko MC. Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats. Eur J Pharmacol. 2014 Dec 15;745:182-9. doi: 10.1016/j.ejphar.2014.10.029. Epub 2014 Oct 29. PMID: 25446568; PMCID: PMC4259829. 2. Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Sałaga M, Storr M, Kordek R, Małecka-Panas E, Krajewska WM, Fichna J. Anti-inflammatory and antinociceptive action of an orally available nociceptin receptor agonist SCH 221510 in a mouse model of inflammatory bowel diseases. J Pharmacol Exp Ther. 2014 Mar;348(3):401-9. doi: 10.1124/jpet.113.209825. Epub 2013 Dec 17. PMID: 24345466.

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1: Sukhtankar DD, Lagorio CH, Ko MC. Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats. Eur J Pharmacol. 2014 Dec 15;745:182-9. doi: 10.1016/j.ejphar.2014.10.029. Epub 2014 Oct 29. PubMed PMID: 25446568; PubMed Central PMCID: PMC4259829.