SC-41930

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532683

CAS#: 120072-59-5

Description: SC-41930, also known as a CGS 24115, is a potent selective leukotriene B4 receptor antagonist.

Chemical Structure

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SC-41930
CAS# 120072-59-5
Instruction

Theoretical Analysis

MedKoo Cat#: 532683
Name: SC-41930
CAS#: 120072-59-5
Chemical Formula: C28H36O7
Exact Mass: 484.25
Molecular Weight: 484.590
Elemental Analysis: C, 69.40; H, 7.49; O, 23.11

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SC-41930; SC 41930; SC41930; CGS 24115; CGS24115.

IUPAC/Chemical Name: 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-8-propylchroman-2-carboxylic acid

InChi Key: ZVVCSBSDFGYRCB-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H36O7/c1-5-8-21-23(13-10-19-11-14-25(28(30)31)35-26(19)21)33-16-7-17-34-24-15-12-20(18(3)29)27(32-4)22(24)9-6-2/h10,12-13,15,25H,5-9,11,14,16-17H2,1-4H3,(H,30,31)

SMILES Code: O=C(C1CCC2=C(O1)C(CCC)=C(OCCCOC3=CC=C(C(C)=O)C(OC)=C3CCC)C=C2)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 484.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sutbeyaz Y, Yakan B, Ozdemir H, Karasen M, Doner F, Kufrevioglu I. Effect of SC-41930, a potent selective leukotriene B4 receptor antagonist, in the guinea pig model of middle ear inflammation. Ann Otol Rhinol Laryngol. 1996 Jun;105(6):476-80. PubMed PMID: 8638901.

2: Penning TD, Djuric SW, Miyashiro JM, Yu S, Snyder JP, Spangler D, Anglin CP, Fretland DJ, Kachur JF, Keith RH, et al. Second-generation leukotriene B4 receptor antagonists related to SC-41930: heterocyclic replacement of the methyl ketone pharmacophore. J Med Chem. 1995 Mar 17;38(6):858-68. PubMed PMID: 7699700.

3: Clapp N, Henke M, Hansard R, Carson R, Walsh R, Widomski D, Anglin C, Fretland D. Inflammatory mediator changes in cotton-top tamarins (CTT) after SC-41930 anti-colitic therapy. Agents Actions. 1993;39 Spec No:C8-10. PubMed PMID: 8273593.

4: Clapp N, Henke M, Hansard R, Carson R, Fretland D. Anti-colitic efficacy of SC-41930 in colitic cotton-top tamarins. Agents Actions. 1993;39 Spec No:C36-8. PubMed PMID: 8273579.

5: Penning TD, Djuric SW, Docter SH, Yu SS, Spangler D, Anglin CP, Fretland DJ, Kachur JF, Keith RH, Tsai BS, et al. The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930. Agents Actions. 1993;39 Spec No:C11-3. PubMed PMID: 8273545.

6: Zimmerman BJ, Gaginella TS, Granger DN. Effects of SC-41930 on leukocyte adherence and emigration in rat mesenteric venules. Agents Actions. 1992 Sep;37(1-2):80-4. PubMed PMID: 1333727.

7: Marder P, Schultz RM, Spaethe SM, Sofia MJ, Herron DK. Flow cytometric evaluation of the effects of leukotriene B4 receptor antagonists (LY255283 and SC-41930) on calcium mobilization and integrin expression of activated human neutrophils. Prostaglandins Leukot Essent Fatty Acids. 1992 Aug;46(4):265-70. PubMed PMID: 1329112.

8: Villani-Price D, Yang DC, Walsh RE, Fretland DJ, Keith RH, Kocan G, Kachur JF, Gaginella TS, Tsai BS. Multiple actions of the leukotriene B4 receptor antagonist SC-41930. J Pharmacol Exp Ther. 1992 Jan;260(1):187-91. PubMed PMID: 1309871.

9: Fretland DJ, Widomski DL, Anglin CP, Levin S, Gaginella TS. Modulation of the chemotactic properties of complement fragments C5a and C3 by the anti-inflammatory agent, SC-41930. Agents Actions. 1991 Sep;34(1-2):5-7. PubMed PMID: 1665303.

10: Fretland DJ, Widomski DL, Shone RL, Levin S, Gaginella TS. Effect of the leukotriene B4 receptor antagonist, SC-41930, on experimental allergic encephalomyelitis (EAE) in the guinea pig. Agents Actions. 1991 Sep;34(1-2):172-4. PubMed PMID: 1665290.

11: Fretland DJ, Widomski DL, Anglin CP, Gaginella TS. The antiinflammatory agent SC-41930 inhibits granulocyte infiltration of the rodent dermis induced by 6-trans-leukotriene B4. Prostaglandins Leukot Essent Fatty Acids. 1991 Sep;44(1):61-5. PubMed PMID: 1658813.

12: Schultz RM, Marder P, Spaethe SM, Herron DK, Sofia MJ. Effects of two leukotriene B4 (LTB4) receptor antagonists (LY255283 and SC-41930) on LTB4-induced human neutrophil adhesion and superoxide production. Prostaglandins Leukot Essent Fatty Acids. 1991 Aug;43(4):267-71. PubMed PMID: 1658812.

13: Kemény L, Ruzicka T. SC-41930, a leukotriene B4 receptor antagonist, inhibits 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) binding to epidermal cells. Agents Actions. 1991 Mar;32(3-4):339-42. PubMed PMID: 1650525.

14: Fretland DJ, Widomski DL, Zemaitis JM, Walsh RE, Levin S, Djuric SW, Shone RL, Tsai BS, Gaginella TS. Inflammation of guinea pig dermis. Effects of leukotriene B4 receptor antagonist, SC-41930. Inflammation. 1990 Dec;14(6):727-39. PubMed PMID: 1965311.

15: Fretland DJ, Widomski D, Tsai BS, Zemaitis JM, Levin S, Djuric SW, Shone RL, Gaginella TS. Effect of the leukotriene B4 receptor antagonist SC-41930 on colonic inflammation in rat, guinea pig and rabbit. J Pharmacol Exp Ther. 1990 Nov;255(2):572-6. PubMed PMID: 2173749.

16: Tsai BS, Villani-Price D, Keith RH, Zemaitis JM, Bauer RF, Leonard R, Djuric SW, Shone RL. SC-41930: an inhibitor of leukotriene B4-stimulated human neutrophil functions. Prostaglandins. 1989 Dec;38(6):655-74. PubMed PMID: 2561214.

17: Fretland DJ, Widomski DL, Shone RL, Penning TD, Miyashiro JM, Djuric SW. SC-41930 inhibits neutrophil infiltration of the cavine dermis induced by 12(R)-hydroxyeicosatetraenoic acid. Prostaglandins Leukot Essent Fatty Acids. 1989 Dec;38(3):169-72. PubMed PMID: 2560200.

18: Fretland DJ, Levin S, Tsai BS, Djurić SW, Widomski DL, Zemaitis JM, Shone RL, Bauer RF. The effect of leukotriene-B4 receptor antagonist, SC-41930, on acetic acid-induced colonic inflammation. Agents Actions. 1989 Jun;27(3-4):395-7. PubMed PMID: 2552769.