SC-19220

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532681

CAS#: 19395-87-0

Description: SC-19220 is a prostaglandin E2 antagonist, inhibits osteoclast formation by 1,25-dihydroxyvitamin D3 in cell cultures.

Chemical Structure

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SC-19220
CAS# 19395-87-0
Instruction

Theoretical Analysis

MedKoo Cat#: 532681
Name: SC-19220
CAS#: 19395-87-0
Chemical Formula: C16H19ClN3O3
Exact Mass: 336.11
Molecular Weight: 336.800
Elemental Analysis: C, 57.06; H, 5.69; Cl, 10.53; N, 12.48; O, 14.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SC-19220; SC 19220; SC19220.

IUPAC/Chemical Name: N'-acetyl-3-chloro-6H-benzo[b][1,5]benzoxazepine-5-carbohydrazide

InChi Key: GJXZKCLXQFGXBS-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19ClN3O3/c1-10(21)19-20-16(22)23-14-5-3-2-4-13(14)18-9-11-6-7-12(17)8-15(11)23/h2-3,6-9,13-15,18H,4-5H2,1H3,(H,19,21)(H,20,22)

SMILES Code: O=C(O1C2C(C=CC(Cl)=C2)=CNC3C1CC=CC3)NNC(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 336.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tsujisawa T, Inoue H, Nishihara T. SC-19220, antagonist of prostaglandin E2 receptor EP1, inhibits osteoclastogenesis by RANKL. J Bone Miner Res. 2005 Jan;20(1):15-22. Epub 2004 Oct 18. PubMed PMID: 15619665.

2: Santangelo S, Shoup M, Gamelli RL, Shankar R. Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis. J Trauma. 2000 May;48(5):826-30; discussion 830-1. PubMed PMID: 10823525.

3: Inoue H, Tsujisawa T, Fukuizumi T, Kawagishi S, Uchiyama C. SC-19220, a prostaglandin E2 antagonist, inhibits osteoclast formation by 1,25-dihydroxyvitamin D3 in cell cultures. J Endocrinol. 1999 May;161(2):231-6. PubMed PMID: 10320820.

4: Vassilev P, Radomirov R. Contractile effects of prostaglandin E2 in rat rectum: sensitivity to the prostaglandin antagonists diphloretin phosphate and SC 19220. Prostaglandins. 1992 Nov;44(5):471-83. PubMed PMID: 1361677.

5: Kimoto Y, Constantinou CE. Regional effects of indomethacin, acetylsalicylic acid and SC-19220 on the contractility of rabbit renal pelvis (pacemaker regions and pelviureteric junction). J Urol. 1991 Aug;146(2):433-8. PubMed PMID: 1677433.

6: Maggi CA, Giuliani S, Patacchini R, Conte B, Furio M, Santicioli P, Meli P, Gragnani L, Meli A. The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats. Eur J Pharmacol. 1988 Aug 2;152(3):273-9. PubMed PMID: 2906002.

7: Rakovska A, Milenov K. Antagonistic effect of SC-19220 on the responses of guinea-pig gastric muscles to prostaglandins E1, E2 and F2 alpha. Arch Int Pharmacodyn Ther. 1984 Mar;268(1):59-69. PubMed PMID: 6145394.

8: Juan H, Seewann S. Selective reduction by some vasodilators and the prostaglandin antagonist SC-19220 of a response to the algesic effect of bradykinin. Eur J Pharmacol. 1980 Jul 25;65(2-3):267-78. PubMed PMID: 6105087.

9: Bennett A, Jarosik C, Sanger GJ, Wilson DE. Antagonism of prostanoid-induced contractions of rat gastric fundus muscle by SC-19220, sodium meclofenamate, indomethacin or trimethoquinol. Br J Pharmacol. 1980;71(1):169-75. PubMed PMID: 6110453; PubMed Central PMCID: PMC2044421.

10: Clark WG, Cumby HR. Effects of prostaglandin antagonist SC-19220 on body temperature and on hyperthermic responses to prostaglandin E-1 and leukocytic pyrogen in the cat. Prostaglandins. 1975 Mar;9(3):361-8. PubMed PMID: 1138292.

11: Lambley JE, Smith AP. The effects of arachidonic acid, indomethacin and SC-19220 on guinea-pig tracheal muscle tone. Eur J Pharmacol. 1975 Feb;30(2):148-53. PubMed PMID: 236189.

12: Farmer JB, Farrar DG, Wilson J. Antagonism of tone and prostaglandin-mediated responses in a tracheal preparation by indomethacin and SC-19220. Br J Pharmacol. 1974 Dec;52(4):559-65. PubMed PMID: 4455330; PubMed Central PMCID: PMC1776897.

13: Engel JJ, Scruggs W, Wilson DE. Failure of SC-19220 to affect prostaglandin E1 (PGR1) gastric antisecretory actions. Prostaglandins. 1973 Jul;4(1):65-70. PubMed PMID: 4199539.

14: Radzialowski FM, Novak L. Reversal of the antilipolytic effect of prostaglandin E 2 by an oxazepine derivative (SC-19220). Life Sci I. 1971 Nov 15;10(22):1261-5. PubMed PMID: 5004183.

15: Sanner JH. Antagonism of prostaglandin E2 by 1-acetyl-2-(8-chloro-10,11-dihydrodibenz (b,f) (1,4) oxazepine-10-carbonyl) hydrazine (SC-19220). Arch Int Pharmacodyn Ther. 1969 Jul;180(1):46-56. PubMed PMID: 4982414.