Fasentin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329652

CAS#: 392721-37-8

Description: Fasentin is an inhibitor of glucose uptake, GluT1 inhibitor. Fasentin sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.


Price and Availability

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Fasentin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329652
Name: Fasentin
CAS#: 392721-37-8
Chemical Formula: C11H9ClF3NO2
Exact Mass: 279.0274
Molecular Weight: 279.6432
Elemental Analysis: C, 47.25; H, 3.24; Cl, 12.68; F, 20.38; N, 5.01; O, 11.44


Synonym: Fasentin

IUPAC/Chemical Name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

InChi Key: GNYIJZMBLZXJEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)

SMILES Code: CC(CC(NC1=CC=C(Cl)C(C(F)(F)F)=C1)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wood TE, Dalili S, Simpson CD, Hurren R, Mao X, Saiz FS, Gronda M, Eberhard Y, Minden MD, Bilan PJ, Klip A, Batey RA, Schimmer AD. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther. 2008 Nov;7(11):3546-55. doi: 10.1158/1535-7163.MCT-08-0569. PubMed PMID: 19001437.

2: Fumarola C, Caffarra C, La Monica S, Galetti M, Alfieri RR, Cavazzoni A, Galvani E, Generali D, Petronini PG, Bonelli MA. Effects of sorafenib on energy metabolism in breast cancer cells: role of AMPK-mTORC1 signaling. Breast Cancer Res Treat. 2013 Aug;141(1):67-78. doi: 10.1007/s10549-013-2668-x. Epub 2013 Aug 21. PubMed PMID: 23963659.

3: Choi HY, Park JH, Jang WB, Ji ST, Jung SY, Kim da Y, Kang S, Kim YJ, Yun J, Kim JH, Baek SH, Kwon SM. High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker. Biomol Ther (Seoul). 2016 Jul 1;24(4):363-70. doi: 10.4062/biomolther.2016.097. PubMed PMID: 27350339; PubMed Central PMCID: PMC4930279.

4: Adekola K, Rosen ST, Shanmugam M. Glucose transporters in cancer metabolism. Curr Opin Oncol. 2012 Nov;24(6):650-4. doi: 10.1097/CCO.0b013e328356da72. Review. PubMed PMID: 22913968.

5: Bhatt AN, Chauhan A, Khanna S, Rai Y, Singh S, Soni R, Kalra N, Dwarakanath BS. Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells. BMC Cancer. 2015 May 1;15:335. doi: 10.1186/s12885-015-1368-9. PubMed PMID: 25925410; PubMed Central PMCID: PMC4425929.

6: Andrisse S, Koehler RM, Chen JE, Patel GD, Vallurupalli VR, Ratliff BA, Warren DE, Fisher JS. Role of GLUT1 in regulation of reactive oxygen species. Redox Biol. 2014 Mar 25;2:764-71. doi: 10.1016/j.redox.2014.03.004. eCollection 2014. PubMed PMID: 25101238; PubMed Central PMCID: PMC4116627.